cis-4-hydroxy-L-proline

Also known as: cis-4-Hydroxyproline, (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid, L-Allo-4-hydroxy-2-pyrrolidinecarboxylic acid, L-Allo-hydroxyproline, cis-4-Hydroxy-L-proline, MFCD00064319, EINECS 210-542-1, CIS-HYDROXYPROLINE, CIS-HYP-OH, CIS-L-4-HYDROXYPROLINE

cis-4-hydroxy-L-proline (CAS 618-27-9) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C5H9NO3 and a molecular weight of 131.130 g/mol. Key properties include a melting point of 257ºC, a boiling point of 355.2±42.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 168.6±27.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 618-27-9
Jingsj CID: J-1072603-1
Molecular Formula: C₅H₉NO₃
Molecular Weight: 131.130 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	257ºC
Boiling Point	355.2±42.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	168.6±27.9 °C
Exact Mass	131.058243
PSA	69.56000
LogP	-1.84
Vapor Pressure	0.0±1.8 mmHg at 25°C
Refractive Index	1.540

Activity & Biological Data

Additional Information	[1]. Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41(7):2855-62. [2]. Kao WW, et, al. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature. 1977 Mar 3;266(5597):63-4. [3]. Tan EM, et, al. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J Invest Dermatol. 1983 Apr;80(4):261-7. [4]. Riley DJ, et, al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):388-93.

Additional Information

[1]. Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41(7):2855-62. [2]. Kao WW, et, al. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature. 1977 Mar 3;266(5597):63-4. [3]. Tan EM, et, al. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J Invest Dermatol. 1983 Apr;80(4):261-7. [4]. Riley DJ, et, al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):388-93.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of cis-4-hydroxy-L-proline?

The CAS number of cis-4-hydroxy-L-proline is 618-27-9.

What are the molecular formula and molecular weight of cis-4-hydroxy-L-proline?

cis-4-hydroxy-L-proline has molecular formula C5H9NO3 and molecular weight 131.130 g/mol.

What are the upstream and downstream products of cis-4-hydroxy-L-proline?

For cis-4-hydroxy-L-proline, Upstream Products: (2S,4S)-1-((Benzyloxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid, (2S,4S)-dibenzyl 4-hydroxypyrrolidine-1,2-dicarboxylate, L-Proline; Downstream Products: L-erythro-4-fluoroglutamic acid, N-Boc-cis-4-hydroxy-L-proline, (2S,4S)-4-Fluoropyrrolidine-2-carboxylic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "cis-4-hydroxy-L-proline (CAS 618-27-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1072603-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.