LY2603618

Also known as: Rabusertib, IC-83, CS-508, 1-[5-bromo-4-methyl-2-[[(2S)-morpholin-2-yl]methoxy]phenyl]-3-(5-methylpyrazin-2-yl)urea, N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N'-(5-methyl-2-pyrazinyl)urea, LY-2603618, LY 2603618, UNII-3S9L1NU6U7

LY2603618 (CAS 911222-45-2) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C18H22BrN5O3 and a molecular weight of 436.303 g/mol. Key properties include a boiling point of 503.1±50.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 258.1±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 911222-45-2
Jingsj CID: J-1011198-1
Molecular Formula: C₁₈H₂₂BrN₅O₃
Molecular Weight: 436.303 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	503.1±50.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	258.1±30.1 °C
Exact Mass	435.090607
PSA	100.89000
LogP	2.10
Vapor Pressure	0.0±1.3 mmHg at 25°C
Refractive Index	1.633
Storage Conditions	-20°C

Activity & Biological Data

Target	Chk1:7 nM (IC50) Chk2:12000 nM (IC50) PDK1:893 nM (IC50) CAMK2:1550 nM (IC50) VEGFR3:2128 nM (IC50) MET:2200 nM (IC50) JNK1:4930 nM (IC50) RSK2:5700 nM (IC50) NTRK1:12000 nM (IC50)
Additional Information	[1]. King C, et al. Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor. Invest New Drugs. 2014 Apr;32(2):213-26. [2]. Wang G, et al. Panobinostat synergistically enhances the cytotoxic effects of cisplatin, doxorubicin or etoposide on high-risk neuroblastoma cells. PLoS One. 2013 Sep 30;8(9):e76662.

Frequently Asked Questions

What is the CAS number of LY2603618?

The CAS number of LY2603618 is 911222-45-2.

What are the molecular formula and molecular weight of LY2603618?

LY2603618 has molecular formula C18H22BrN5O3 and molecular weight 436.303 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "LY2603618 (CAS 911222-45-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1011198-1 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.