protocatechuic acid
Also known as: 3,4-Dihydroxybenzoic acid, Protocatechuate, PCA, 4-Carboxy-1,2-dihydroxybenzene, 4-Carboxycatechol, Hypogallic acid, 3,4-dihydroxybenzoate
protocatechuic acid (CAS 99-50-3) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C7H6O4 and a molecular weight of 154.120 g/mol. Key properties include a melting point of 197-200 °C (dec.)(lit.), a boiling point of 410.7±35.0 °C at 760 mmHg, a density of 1.6±0.1 g/cm3 and a flash point of 216.3±22.4 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. It is listed by 1 supplier; request a quote for pricing. Record last updated Aug 21, 2026.
- CAS No.
- 99-50-3
- Jingsj CID
- J-48044-0
- Molecular Formula
- C7H6O4
- Molecular Weight
- 154.120 g/mol
- Category
- Organic Acids
- Last updated
- 8/21/2026
| Supplier | Purity / Pack | Base Price | Unit Price | Origin | |
|---|---|---|---|---|---|
Made to Order | - | - | CN China |
Physicochemical Properties
| Melting Point | 197-200 °C (dec.)(lit.) |
|---|---|
| Boiling Point | 410.7±35.0 °C at 760 mmHg |
| Density | 1.6±0.1 g/cm3 |
| Flash Point | 216.3±22.4 °C |
| Exact Mass | 154.026611 |
| PSA | 77.76000 |
| LogP | 1.16 |
| Vapor Pressure | 0.0±1.0 mmHg at 25°C |
| Refractive Index | 1.671 |
GHS Safety & Compliance
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Additional Information | [1]. Thakare VN, et al. Attenuation of acute restraint stress-induced depressive like behavior and hippocampal alterations with protocatechuic acid treatment in mice. Metab Brain Dis. 2016 Oct 26. [2]. Adefegha SA, et al. Alterations of Na+/K+-ATPase, cholinergic and antioxidant enzymes activity by protocatechuic acid in cadmium-induced neurotoxicity and oxidative stress in Wistar rats. Biomed Pharmacother. 2016 Oct;83:559-568. [3]. Hornedo-Ortega R, et al. Protocatechuic Acid: Inhibition of Fibril Formation, Destabilization of Preformed Fibrils of Amyloid-β and α-Synuclein, and Neuroprotection. J Agric Food Chem. 2016 Oct 10. |
|---|
Customs & Trade Information
| HS Code | 2918290000 |
|---|---|
| Summary | HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0% |
Frequently Asked Questions
What is the CAS number of protocatechuic acid?
The CAS number of protocatechuic acid is 99-50-3.
What are the molecular formula and molecular weight of protocatechuic acid?
protocatechuic acid has molecular formula C7H6O4 and molecular weight 154.120 g/mol.
Which suppliers offer protocatechuic acid?
1 supplier(s) listed; request a quote for pricing.
Is protocatechuic acid hazardous?
protocatechuic acid has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.
What are the upstream and downstream products of protocatechuic acid?
For protocatechuic acid, Upstream Products: 3,4-Dihydroxymandelic acid, Quercetin, Vanillin; Downstream Products: Methyl 2,4-dimethoxybenzoate, Methyl 2-methoxybenzoate, Methyl 3-methoxybenzoate.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "protocatechuic acid (CAS 99-50-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-48044-0 (accessed 2026-11-07).
Data for reference only; verify product details with suppliers before purchase.