Nafcillin sodium

Also known as: Nafcillin sodium salt, Sodium nafcillin, Nafcillin, NAFCILLIN SODIUM SALT, Unipen, Naftopen, Wy 3277, BRL 1383, sodium (2S,5R,6R)-6-[(2-ethoxy-1-naphthyl)carbonyl]amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate, sodium 6-(2-ethoxy-1-naphthamido)penicillanate

Nafcillin sodium (CAS 985-16-0) is a compound in the Aromatic Hydrocarbons category listed in the Jingsj chemical database. It has the molecular formula C21H21N2NaO5S and a molecular weight of 436.45700 g/mol. Key properties include a boiling point of 714.1ºC at 760mmHg, a density of 1.42g/cm3 and a flash point of 385.7ºC. It is classified under GHS with signal word Danger and hazard statements H317 — May cause an allergic skin reaction and H334 — May cause allergy or asthma symptoms if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 985-16-0
Jingsj CID: J-1764-8
Molecular Formula: C₂₁H₂₁N₂NaO₅S
Molecular Weight: 436.45700 g/mol
Category: Aromatic Hydrocarbons
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	714.1ºC at 760mmHg
Density	1.42g/cm3
Flash Point	385.7ºC
Exact Mass	436.10700
PSA	124.07000
LogP	1.47790
Storage Conditions	Store at 0-5°C

GHS Safety & Compliance

Health HazardSignal word: Danger

H317 — May cause an allergic skin reaction
H334 — May cause allergy or asthma symptoms if inhaled

Activity & Biological Data

Additional Information	[1]. Tan AK, et, al. Identification of the site of covalent attachment of nafcillin, a reversible suicide inhibitor of beta-lactamase. Biochem J. 1992 Jan 1;281 ( Pt 1)(Pt 1):191-6. [2]. Palmer DL, et, al. Bacterial wound colonization after broad-spectrum versus narrow-spectrum antibiotics. Ann Thorac Surg. 1995 Mar;59(3):626-31. [3]. Monogue ML, et, al. Nafcillin versus cefazolin for the treatment of methicillin-susceptible Staphylococcus aureus bacteremia. J Infect Public Health. Sep-Oct 2018;11(5):727-731.

Additional Information

[1]. Tan AK, et, al. Identification of the site of covalent attachment of nafcillin, a reversible suicide inhibitor of beta-lactamase. Biochem J. 1992 Jan 1;281 ( Pt 1)(Pt 1):191-6. [2]. Palmer DL, et, al. Bacterial wound colonization after broad-spectrum versus narrow-spectrum antibiotics. Ann Thorac Surg. 1995 Mar;59(3):626-31. [3]. Monogue ML, et, al. Nafcillin versus cefazolin for the treatment of methicillin-susceptible Staphylococcus aureus bacteremia. J Infect Public Health. Sep-Oct 2018;11(5):727-731.

Frequently Asked Questions

What is the CAS number of Nafcillin sodium?

The CAS number of Nafcillin sodium is 985-16-0.

What are the molecular formula and molecular weight of Nafcillin sodium?

Nafcillin sodium has molecular formula C21H21N2NaO5S and molecular weight 436.45700 g/mol.

Is Nafcillin sodium hazardous?

Nafcillin sodium has GHS signal word Danger and hazard statements H317 — May cause an allergic skin reaction; H334 — May cause allergy or asthma symptoms if inhaled.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Nafcillin sodium (CAS 985-16-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1764-8 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.