Canrenone

Also known as: Aldadiene, SC9376, SC14266, Phanurane, Contaren, Luvion, 11614 R.P., 6-Dehydrotestosterone-17α-propionic acid γ-lactone, 3-(3-Oxo-17β-hydroxy-4,6-androstadien-17α-yl)propionic acid γ-lactone, (17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone, Spiro[17H-cyclopenta[a]phenanthrene-17,2'(5'H)-furan]-3,5'(2H)-dione, 1,3',4',8,9,10,11,12,13,14,15,16-dodecahydro-10,13-dimethyl-, (8R,9S,10R,13S,14S,17R)-, Canrenone-D4

Canrenone (CAS 976-71-6) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C22H28O3 and a molecular weight of 340.456 g/mol. Key properties include a melting point of 158-160ºC, a boiling point of 541.1±50.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 237.6±30.2 °C. It is classified under GHS with signal word Warning and hazard statements H351 — Suspected of causing cancer and H411 — Toxic to aquatic life with long lasting effects. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 976-71-6
Jingsj CID: J-1962906-2
Molecular Formula: C₂₂H₂₈O₃
Molecular Weight: 340.456 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	158-160ºC
Boiling Point	541.1±50.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	237.6±30.2 °C
Exact Mass	340.203857
PSA	43.37000
LogP	2.99
Vapor Pressure	0.0±1.4 mmHg at 25°C
Refractive Index	1.581

GHS Safety & Compliance

Health Hazard / Environmental HazardSignal word: Warning

H351 — Suspected of causing cancer
H411 — Toxic to aquatic life with long lasting effects

Activity & Biological Data

Target	Target: Aldosterone[1]
Additional Information	[1]. Erbler HC, et al. On the mechanism of the inhibitory action of the spirolactone SC 9376 (aldadiene) on the production of corticosteroids in rat adrenals in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1973;277(2):139-49. [2]. Caligiuri A, et al. Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells. Gastroenterology. 2003 Feb;124(2):504-20. [3]. Erbler HC, et al. Effect of spironolactone and its main metabolite canrenone on the renin-angiotensin-aldosterone-system during long-term treatment in rats. Acta Endocrinol (Copenh). 1979 Jan;90(1):147-56.

Target

Target: Aldosterone[1]

Additional Information

[1]. Erbler HC, et al. On the mechanism of the inhibitory action of the spirolactone SC 9376 (aldadiene) on the production of corticosteroids in rat adrenals in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1973;277(2):139-49. [2]. Caligiuri A, et al. Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells. Gastroenterology. 2003 Feb;124(2):504-20. [3]. Erbler HC, et al. Effect of spironolactone and its main metabolite canrenone on the renin-angiotensin-aldosterone-system during long-term treatment in rats. Acta Endocrinol (Copenh). 1979 Jan;90(1):147-56.

Frequently Asked Questions

What is the CAS number of Canrenone?

The CAS number of Canrenone is 976-71-6.

What are the molecular formula and molecular weight of Canrenone?

Canrenone has molecular formula C22H28O3 and molecular weight 340.456 g/mol.

Is Canrenone hazardous?

Canrenone has GHS signal word Warning and hazard statements H351 — Suspected of causing cancer; H411 — Toxic to aquatic life with long lasting effects.

What are the upstream and downstream products of Canrenone?

For Canrenone, Upstream Products: 7α-Thiospironolactone, Spironolactone, Ethisterone; Downstream Products: Spironolactone, 11α-Hydroxy Canrenone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Canrenone (CAS 976-71-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1962906-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.