Piperine

Also known as: 1-Piperoylpiperidine, (E,E)-1-Piperoylpiperidine, Bioperine, Piperin, 1-Piperonylpiperidine, 1-Piperylpiperidine, FEMA 2909, UNII:U71XL721QK, (2E,4E)-5-(1,3-Benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one, 1-(5-(3,4-Methylenedioxyphenyl)-1-oxo-2,4-pentadienyl)piperidine

Piperine (CAS 94-62-2) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C17H19NO3 and a molecular weight of 285.338 g/mol. Key properties include a melting point of 131-135 °C(lit.), a boiling point of 498.5±40.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 255.3±27.3 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 94-62-2
Jingsj CID: J-37143-8
Molecular Formula: C₁₇H₁₉NO₃
Molecular Weight: 285.338 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	131-135 °C(lit.)
Boiling Point	498.5±40.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	255.3±27.3 °C
Exact Mass	285.136505
PSA	38.77000
LogP	2.66
Vapor Pressure	0.0±1.3 mmHg at 25°C
Refractive Index	1.615
Additional Property	40 mg/L (18 ºC)

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Target	IC50: 61.94±0.054 μg/mL (P-glycoprotein, HeLa cell)[1]
Additional Information	[1]. Paarakh PM, et al. In vitro cytotoxic and in silico activity of piperine isolated from Piper nigrum fruits Linn. In Silico Pharmacol. 2015 Dec;3(1):9. Epub 2015 Oct 29. [2]. Meghwal M,et al. Piper nigrum and piperine: an update. Phytother Res. 2013 Aug;27(8):1121-30. [3]. Li C, et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93. [4]. Zhai WJ, et al. Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice. Evid Based Complement Alternat Med. 2016;2016:8597208.

Target

IC50: 61.94±0.054 μg/mL (P-glycoprotein, HeLa cell)[1]

Additional Information

[1]. Paarakh PM, et al. In vitro cytotoxic and in silico activity of piperine isolated from Piper nigrum fruits Linn. In Silico Pharmacol. 2015 Dec;3(1):9. Epub 2015 Oct 29. [2]. Meghwal M,et al. Piper nigrum and piperine: an update. Phytother Res. 2013 Aug;27(8):1121-30. [3]. Li C, et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93. [4]. Zhai WJ, et al. Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice. Evid Based Complement Alternat Med. 2016;2016:8597208.

Customs & Trade Information

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Piperine?

The CAS number of Piperine is 94-62-2.

What are the molecular formula and molecular weight of Piperine?

Piperine has molecular formula C17H19NO3 and molecular weight 285.338 g/mol.

Is Piperine hazardous?

Piperine has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

What are the upstream and downstream products of Piperine?

For Piperine, Upstream Products: Piperic acid, 1-(piperidin-1-yl)prop-2-en-1-one, 3,4-(Methylenedioxy)cinnamic acid; Downstream Products: Tetraethyl ethylenetetracarboxylate, 1-Nitrosopiperidine, Piperic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Piperine (CAS 94-62-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-37143-8 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.