Ethoxyquin

Also known as: 6-Ethoxy-1,2-dihydro-2,2,4-trimethylquinoline, 1,2-Dihydro-6-ethoxy-2,2,4-trimethylquinoline, 6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline, 6-Ethoxyl-2,2,4-trimethyl-1,2-dihydrquinoline, Santoquin, Santoflex, Antioxidant AW, EMQ, EQ, UNII-9T1410R4OR, Niflex, Nocrac AW, Antage AW, USAF B-24, MFCD00023883

Ethoxyquin (CAS 91-53-2) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C14H19NO and a molecular weight of 217.307 g/mol. Key properties include a melting point of <0ºC, a boiling point of 333.1±42.0 °C at 760 mmHg, a density of 1.0±0.1 g/cm3 and a flash point of 137.8±17.3 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Nov 3, 2026.

CAS No.: 91-53-2
Jingsj CID: J-1968440-2
Molecular Formula: C₁₄H₁₉NO
Molecular Weight: 217.307 g/mol
Category: Pharma Intermediates
Last updated: 11/3/2026

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Physicochemical Properties

Melting Point	<0ºC
Boiling Point	333.1±42.0 °C at 760 mmHg
Density	1.0±0.1 g/cm3
Flash Point	137.8±17.3 °C
Exact Mass	217.146667
PSA	21.26000
LogP	3.93
Vapor Pressure	0.0±0.7 mmHg at 25°C
Refractive Index	1.512
Additional Property	ethanol: 50 mL/L, clear, brown \| <0.1 g/100 mL at 20 ºC

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Target	HSP90
Additional Information	[1]. Sadikot T, et al. Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors. Assay Drug Dev Technol. 2013 Oct;11(8):478-88. [2]. Zhu J, et al. Ethoxyquin prevents chemotherapy-induced neurotoxicity via Hsp90 modulation. Ann Neurol. 2013 Dec;74(6):893-904. [3]. Zhu J, et al. Ethoxyquin provides neuroprotection against cisplatin-induced neurotoxicity. Sci Rep. 2016 Jun 28;6:28861.

Target

HSP90

Additional Information

[1]. Sadikot T, et al. Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors. Assay Drug Dev Technol. 2013 Oct;11(8):478-88. [2]. Zhu J, et al. Ethoxyquin prevents chemotherapy-induced neurotoxicity via Hsp90 modulation. Ann Neurol. 2013 Dec;74(6):893-904. [3]. Zhu J, et al. Ethoxyquin provides neuroprotection against cisplatin-induced neurotoxicity. Sci Rep. 2016 Jun 28;6:28861.

Customs & Trade Information

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Ethoxyquin?

The CAS number of Ethoxyquin is 91-53-2.

What are the molecular formula and molecular weight of Ethoxyquin?

Ethoxyquin has molecular formula C14H19NO and molecular weight 217.307 g/mol.

Is Ethoxyquin hazardous?

Ethoxyquin has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

What are the upstream and downstream products of Ethoxyquin?

For Ethoxyquin, Upstream Products: p-Phenetidine, Diacetone alcohol; Downstream Products: 2-(1-Cyclohexen-1-yl)cyclohexanone, 2-cyclopentylidenecyclopentan-1-one.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 11/3/2026

How to cite: Jingsj. "Ethoxyquin (CAS 91-53-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1968440-2 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.