(R)-(-)-Gossypol

(R)-(-)-棉子酚

Also known as: AT-101, (R)-Gossypol, (-)-Gossypol, R-(-)-Gossypol, Gossypol, (R)-, CS-619

(R)-(-)-Gossypol (CAS 90141-22-3) is a compound in the Alcohols category listed in the Jingsj chemical database. It has the molecular formula C30H30O8 and a molecular weight of 518.554 g/mol. It is also known as AT-101, (R)-Gossypol and (-)-Gossypol. Key properties include a melting point of 166-167ºC, a boiling point of 707.9±55.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 395.9±28.0 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 90141-22-3
Jingsj CID: J-1981971-6
Molecular Formula: C₃₀H₃₀O₈
Chinese Name: (R)-(-)-棉子酚
Molecular Weight: 518.554 g/mol
Category: Alcohols
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	166-167ºC
Boiling Point	707.9±55.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	395.9±28.0 °C
Exact Mass	518.194092
PSA	155.52000
LogP	6.16
Vapor Pressure	0.0±2.3 mmHg at 25°C
Refractive Index	1.742

Activity & Biological Data

Target	Bcl-2:260 nM (Ki) Bcl-xL:480 nM (Ki) Mcl-1:170 nM (Ki) Autophagy
Additional Information	[1]. Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63. [2]. Sun Y, et al. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7(9):1418-26.

Target

Bcl-2:260 nM (Ki) Bcl-xL:480 nM (Ki) Mcl-1:170 nM (Ki) Autophagy

Additional Information

[1]. Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63. [2]. Sun Y, et al. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7(9):1418-26.

Frequently Asked Questions

What is the CAS number of (R)-(-)-Gossypol?

The CAS number of (R)-(-)-Gossypol is 90141-22-3.

What are the molecular formula and molecular weight of (R)-(-)-Gossypol?

(R)-(-)-Gossypol has molecular formula C30H30O8 and molecular weight 518.554 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "(R)-(-)-Gossypol (CAS 90141-22-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1981971-6 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.