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Leptomycin A

来普霉素A

Also known as: Antibiotic ATS-1287A, Antibiotic PD-118607, Jildamycin, NSC 369326, PD-118607, 19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid, (2E,10E,12E,16E,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid, 2,10,12,16,18-Nonadecapentaenoic acid,19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-, 2,10,12,16,18-Nonadecapentaenoic acid,19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-, 2,10,12,16,18-Nonadecapentaenoicacid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-, ATS 1287A, PD 118607, JildaMycin

Leptomycin A (CAS 87081-36-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C32H46O6 and a molecular weight of 526.70400 g/mol. It is also known as Antibiotic ATS-1287A, Antibiotic PD-118607 and Jildamycin. Key properties include a boiling point of 717.7ºC at 760 mmHg, a density of 1.079g/cm3 and a flash point of 224.2ºC. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour, H301 — Toxic if swallowed and H311 — Toxic in contact with skin. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.
87081-36-5
Jingsj CID
J-1958230-8
Molecular Formula
C32H46O6
Chinese Name
来普霉素A
Molecular Weight
526.70400 g/mol
Category
Organic Compounds
Last updated
8/21/2026

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Physicochemical Properties

Boiling Point717.7ºC at 760 mmHg
Density1.079g/cm3
Flash Point224.2ºC
Exact Mass526.32900
PSA100.90000
LogP6.39460
Refractive Index1.544
Storage Conditions?20°C

GHS Safety & Compliance

Flammable / Acute Toxicity / Health HazardSignal word: Danger
  • H225 — Highly flammable liquid and vapour
  • H301 — Toxic if swallowed
  • H311 — Toxic in contact with skin
  • H331 — Toxic if inhaled
  • H370 — Causes damage to organs

Activity & Biological Data

TargetCRM1[1][2].
Additional Information[1]. Kudo, N., et al. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell Res. 242(2), 540-547 (1998). [2]. Wolff B, et al. Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem Biol. 1997 Feb;4(2):139-47.

Frequently Asked Questions

What is the CAS number of Leptomycin A?

The CAS number of Leptomycin A is 87081-36-5.

What are the molecular formula and molecular weight of Leptomycin A?

Leptomycin A has molecular formula C32H46O6 and molecular weight 526.70400 g/mol.

Is Leptomycin A hazardous?

Leptomycin A has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H301 — Toxic if swallowed; H311 — Toxic in contact with skin.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "Leptomycin A (CAS 87081-36-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1958230-8 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.