Leptomycin B
来普霉素B
Also known as: CI 940, LMB, Elactocin, PD 114720, Antibiotic CI 940, Antibiotic CL 1957A, (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid, Leptomycin B from Streptomyces sp.
Leptomycin B (CAS 87081-35-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C33H48O6 and a molecular weight of 540.73 g/mol. It is also known as CI 940, LMB and Elactocin. Key properties include a melting point of 41-44ºC, a boiling point of 725.8±60.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 224.8±26.4 °C. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour, H301 — Toxic if swallowed and H311 — Toxic in contact with skin. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 87081-35-4
- Jingsj CID
- J-1959977-7
- Molecular Formula
- C33H48O6
- Chinese Name
- 来普霉素B
- Molecular Weight
- 540.73 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 41-44ºC |
|---|---|
| Boiling Point | 725.8±60.0 °C at 760 mmHg |
| Density | 1.1±0.1 g/cm3 |
| Flash Point | 224.8±26.4 °C |
| Exact Mass | 540.345093 |
| PSA | 100.90000 |
| LogP | 6.66 |
| Vapor Pressure | 0.0±5.3 mmHg at 25°C |
| Refractive Index | 1.542 |
GHS Safety & Compliance
- H225 — Highly flammable liquid and vapour
- H301 — Toxic if swallowed
- H311 — Toxic in contact with skin
- H331 — Toxic if inhaled
- H370 — Causes damage to organs
Activity & Biological Data
| Target | CRM1/exportin 1[1] |
|---|---|
| Additional Information | [1]. Kudo N, et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9112-7. |
Customs & Trade Information
| HS Code | 2916190090 |
|---|---|
| Summary | 2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0% |
Frequently Asked Questions
What is the CAS number of Leptomycin B?
The CAS number of Leptomycin B is 87081-35-4.
What are the molecular formula and molecular weight of Leptomycin B?
Leptomycin B has molecular formula C33H48O6 and molecular weight 540.73 g/mol.
Is Leptomycin B hazardous?
Leptomycin B has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H301 — Toxic if swallowed; H311 — Toxic in contact with skin.
Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Leptomycin B (CAS 87081-35-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959977-7 (accessed 2026-10-28).
Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.