1-(5-isoquinolinylsulfonyl)-2-methylpiperazine

Also known as: H-7, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine, Isoquinoline-5-sulfonic 2-methyl-1-piperazide, 5-(2-methylpiperazine-1-sulfonyl)isoquinoline, Protein kinase inhibitor H-7

1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (CAS 84477-87-2) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C14H17N3O2S and a molecular weight of 291.36900 g/mol. Key properties include a melting point of 114 °C, a boiling point of 495.3ºC at 760 mmHg, a density of 1.277 g/cm3 and a flash point of 253.3ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 84477-87-2
Jingsj CID: J-1959964-3
Molecular Formula: C₁₄H₁₇N₃O₂S
Molecular Weight: 291.36900 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	114 °C
Boiling Point	495.3ºC at 760 mmHg
Density	1.277 g/cm3
Flash Point	253.3ºC
Exact Mass	291.10400
PSA	70.68000
LogP	2.56470
Refractive Index	1.652
Storage Conditions	2-8°C

Activity & Biological Data

Target	PKC:6 μM (Ki)
Additional Information	[1]. Hidaka H, et, al. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry. 1984 Oct 9;23(21):5036-41.

Customs & Trade Information

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Frequently Asked Questions

What is the CAS number of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine?

The CAS number of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine is 84477-87-2.

What are the molecular formula and molecular weight of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine?

1-(5-isoquinolinylsulfonyl)-2-methylpiperazine has molecular formula C14H17N3O2S and molecular weight 291.36900 g/mol.

What are the upstream and downstream products of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine?

For 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, Upstream Products: 2-Methylpiperazine, benzyl 3-methylpiperazine-1-carboxylate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (CAS 84477-87-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959964-3 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.