Rottlerin

粗糠柴苦素

Also known as: Mallotoxin, Kamalin, NSC 56346, NSC 94525, 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone, (2E)-1-[6-(3-Acetyl-2,4,6-trihydroxy-5-methylbenzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-3-phenylprop-2-en-1-one, 5,7-Dihydroxy-2,2-dimethyl-6-(2,4,6-trihydroxy-3-methyl-5-acetylbenzyl)-8-cinnamoyl-1,2-chromene

Rottlerin (CAS 82-08-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C30H28O8 and a molecular weight of 516.539 g/mol. It is also known as Mallotoxin, Kamalin and NSC 56346. Key properties include a melting point of 200 °C, a boiling point of 800.4±65.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 266.0±27.8 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 82-08-6
Jingsj CID: J-28090-9
Molecular Formula: C₃₀H₂₈O₈
Chinese Name: 粗糠柴苦素
Molecular Weight: 516.539 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	200 °C
Boiling Point	800.4±65.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	266.0±27.8 °C
Exact Mass	516.178406
PSA	144.52000
LogP	8.66
Vapor Pressure	0.0±2.9 mmHg at 25°C
Refractive Index	1.682

Activity & Biological Data

Target	PKCδ:3 μM (IC50, Porcine spleen) PKCα:30 μM (IC50, baculovirus-infected Sf9 insect cells) PKCγ:40 μM (IC50, baculovirus-infected Sf9 insect cells) PKCβ:42 μM (IC50, baculovirus-infected Sf9 insect cells) PKCη:82 μM (IC50, baculovirus-infected Sf9 insect cells) PKCζ:100 μM (IC50, baculovirus-infected Sf9 insect cells) PKCε:100 μM (IC50, baculovirus-infected Sf9 insect cells) CaM kinase III:5.3 μM (IC50, EF-2 kinase activity in cytosol of murine pancreas) CKII:30 μM (IC50, holoenzyme expressed in E.coli) PKA:78 μM (IC50, catalytic subunit from porcine heart)
Additional Information	[1]. Gschwendt M, et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994 Feb 28;199(1):93-8. [2]. Jane EP, et al. Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. J Pharmacol Exp Ther. 2006 Dec;319(3):1070-80.

Target

PKCδ:3 μM (IC50, Porcine spleen) PKCα:30 μM (IC50, baculovirus-infected Sf9 insect cells) PKCγ:40 μM (IC50, baculovirus-infected Sf9 insect cells) PKCβ:42 μM (IC50, baculovirus-infected Sf9 insect cells) PKCη:82 μM (IC50, baculovirus-infected Sf9 insect cells) PKCζ:100 μM (IC50, baculovirus-infected Sf9 insect cells) PKCε:100 μM (IC50, baculovirus-infected Sf9 insect cells) CaM kinase III:5.3 μM (IC50, EF-2 kinase activity in cytosol of murine pancreas) CKII:30 μM (IC50, holoenzyme expressed in E.coli) PKA:78 μM (IC50, catalytic subunit from porcine heart)

Additional Information

[1]. Gschwendt M, et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994 Feb 28;199(1):93-8. [2]. Jane EP, et al. Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. J Pharmacol Exp Ther. 2006 Dec;319(3):1070-80.

Frequently Asked Questions

What is the CAS number of Rottlerin?

The CAS number of Rottlerin is 82-08-6.

What are the molecular formula and molecular weight of Rottlerin?

Rottlerin has molecular formula C30H28O8 and molecular weight 516.539 g/mol.

What are the upstream and downstream products of Rottlerin?

For Rottlerin, Downstream Products: 3-Phenylpropionic acid, 4-Nitrocinnamic acid, 2-Nitrobenzoic acid.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Rottlerin (CAS 82-08-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-28090-9 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.