Trequinsin hydrochloride

Also known as: HL 725, HL 725 HCL, Trequinsin, HCl, 2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride, 9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one hydrochloride, Trequinsine

Trequinsin hydrochloride (CAS 78416-81-6) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C24H28ClN3O3 and a molecular weight of 441.95000 g/mol. Key properties include a boiling point of 613.8ºC at 760 mmHg and a flash point of 325ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 78416-81-6
Jingsj CID: J-49676-2
Molecular Formula: C₂₄H₂₈ClN₃O₃
Molecular Weight: 441.95000 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	613.8ºC at 760 mmHg
Flash Point	325ºC
Exact Mass	441.18200
PSA	57.75000
LogP	4.38670

Activity & Biological Data

Additional Information	[1]. D Ruppert,, et al. HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro. Life Sci. 1982 Nov 8;31(19):2037-43. [2]. K C Agarwal, et al. Role of plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor of cAMP phosphodiesterase: species differences. Thromb Res. 1987 Jul 15;47(2):191-200. [3]. Rachel C McBrinn, et al. Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function. Br J Pharmacol. 2019 Dec;176(23):4521-4536.

Additional Information

[1]. D Ruppert,, et al. HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro. Life Sci. 1982 Nov 8;31(19):2037-43. [2]. K C Agarwal, et al. Role of plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor of cAMP phosphodiesterase: species differences. Thromb Res. 1987 Jul 15;47(2):191-200. [3]. Rachel C McBrinn, et al. Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function. Br J Pharmacol. 2019 Dec;176(23):4521-4536.

Frequently Asked Questions

What is the CAS number of Trequinsin hydrochloride?

The CAS number of Trequinsin hydrochloride is 78416-81-6.

What are the molecular formula and molecular weight of Trequinsin hydrochloride?

Trequinsin hydrochloride has molecular formula C24H28ClN3O3 and molecular weight 441.95000 g/mol.

What are the upstream and downstream products of Trequinsin hydrochloride?

For Trequinsin hydrochloride, Upstream Products: iodomethane.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Trequinsin hydrochloride (CAS 78416-81-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-49676-2 (accessed 2026-10-29).

Data for reference only; verify product details with suppliers before purchase.