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Chlorthalidone

Also known as: Chlortalidone, Chlorthalidone, Hygroton, Thalitone, 2-Chloro-5-(1-hydroxy-3-oxoisoindolin-1-yl)benzenesulfonamide, 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide, 1-oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline, 1-keto-3-(3'-sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline, (±)-Chlorthalidone, (±)-Hygroton, Benzenesulfonamide, 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-, EINECS 201-022-5, MFCD00036257, Higroton

Chlorthalidone (CAS 77-36-1) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C14H11ClN2O4S and a molecular weight of 338.766 g/mol. Key properties include a melting point of 265-267ºC (dec.) and a density of 1.6±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.
77-36-1
Jingsj CID
J-26427-7
Molecular Formula
C14H11ClN2O4S
Molecular Weight
338.766 g/mol
Category
Ketones
Last updated
8/21/2026

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Physicochemical Properties

Melting Point265-267ºC (dec.)
Density1.6±0.1 g/cm3
Exact Mass338.012817
PSA117.87000
LogP-0.74
Refractive Index1.694
Additional PropertyDMSO: soluble5mg/mL, clear (warmed)

Activity & Biological Data

Additional Information[1]. Barrios V, et al. Which thiazide to choose as add-on therapy for hypertension? Integr Blood Press Control. 2014 Jul 30;7:35-47. [2]. Ettinger B, et al. Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. J Urol. 1988 Apr;139(4):679-84.

Customs & Trade Information

HS Code2935009090
Summary2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Frequently Asked Questions

What is the CAS number of Chlorthalidone?

The CAS number of Chlorthalidone is 77-36-1.

What are the molecular formula and molecular weight of Chlorthalidone?

Chlorthalidone has molecular formula C14H11ClN2O4S and molecular weight 338.766 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "Chlorthalidone (CAS 77-36-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-26427-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.