Camptothecin

Also known as: (S)-(+)-Camptothecin, (20S)-Camptothecin, (S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, Camptothecine, d-Camptothecin, CaMptothecin, CaMpathecin, CPT, MFCD00081076, EINECS 444-280-6

Camptothecin (CAS 7689-03-4) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C20H16N2O4 and a molecular weight of 348.352 g/mol. Key properties include a melting point of 260 °C (dec.)(lit.), a boiling point of 757.0±60.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 411.6±32.9 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 7689-03-4
Jingsj CID: J-11410-7
Molecular Formula: C₂₀H₁₆N₂O₄
Molecular Weight: 348.352 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	260 °C (dec.)(lit.)
Boiling Point	757.0±60.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	411.6±32.9 °C
Exact Mass	348.110992
PSA	81.42000
LogP	1.60
Vapor Pressure	0.0±2.7 mmHg at 25°C
Refractive Index	1.746
Storage Conditions	2-8℃
Additional Property	insoluble

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed

Activity & Biological Data

Target	Topoisomerase I:679 nM (IC50)
Additional Information	[1]. Hertzberg RP, et al. Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site. J Biol Chem. 1990 Nov 5;265(31):19287-95. [2]. Hsiang YH, et al. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem. 1985 Nov 25;260(27):14873-8. [3]. Luzzio MJ, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I.

Target

Topoisomerase I:679 nM (IC50)

Additional Information

[1]. Hertzberg RP, et al. Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site. J Biol Chem. 1990 Nov 5;265(31):19287-95. [2]. Hsiang YH, et al. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem. 1985 Nov 25;260(27):14873-8. [3]. Luzzio MJ, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I.

Frequently Asked Questions

What is the CAS number of Camptothecin?

The CAS number of Camptothecin is 7689-03-4.

What are the molecular formula and molecular weight of Camptothecin?

Camptothecin has molecular formula C20H16N2O4 and molecular weight 348.352 g/mol.

Is Camptothecin hazardous?

Camptothecin has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.

What are the upstream and downstream products of Camptothecin?

For Camptothecin, Upstream Products: 4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, (4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione; Downstream Products: Rubitecan, 9-Aminocamptothecin, 7-Ethyl-10-hydroxycamptothecin.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Camptothecin (CAS 7689-03-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-11410-7 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.