HEPES

4-羟乙基哌嗪乙磺酸

Also known as: 4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid, 2-[4-(2-Hydroxyethyl)-1-piperazinyl]ethanesulfonic acid, N-(2-Hydroxyethyl)piperazine-N'-(2-ethanesulfonic acid), HEPES buffer, Good's buffer, HEPES free acid, 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid

HEPES (CAS 7365-45-9) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C8H18N2O4S and a molecular weight of 238.305 g/mol. It is also known as 4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid, 2-[4-(2-Hydroxyethyl)-1-piperazinyl]ethanesulfonic acid and N-(2-Hydroxyethyl)piperazine-N'-(2-ethanesulfonic acid). Key properties include a melting point of 234-238 °C and a density of 1.3±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 7365-45-9
Jingsj CID: J-1107086-3
Molecular Formula: C₈H₁₈N₂O₄S
Chinese Name: 4-羟乙基哌嗪乙磺酸
Molecular Weight: 238.305 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	234-238 °C
Density	1.3±0.1 g/cm3
Exact Mass	238.098724
PSA	89.46000
LogP	-2.67
Refractive Index	1.543
Additional Property	Soluble

Activity & Biological Data

Additional Information	[1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492. [3]. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 2018;14(3):437-449.

Additional Information

[1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492. [3]. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 2018;14(3):437-449.

Customs & Trade Information

HS Code	29335995

Frequently Asked Questions

What is the CAS number of HEPES?

The CAS number of HEPES is 7365-45-9.

What are the molecular formula and molecular weight of HEPES?

HEPES has molecular formula C8H18N2O4S and molecular weight 238.305 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "HEPES (CAS 7365-45-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1107086-3 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.