Felodipine

非洛地平

Also known as: (RS)-Felodipine, (±)-Felodipine, Agon, CGH-869, Ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate, Feloday, Flodil, Hydac, Modip, Munobal, Plendil, Prevex, Renedil, Spendil, Splendil, h154/82

Felodipine (CAS 72509-76-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C18H19Cl2NO4 and a molecular weight of 384.254 g/mol. It is also known as (RS)-Felodipine, (±)-Felodipine and Agon. Key properties include a melting point of 142-145°C, a boiling point of 471.5±45.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 239.0±28.7 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 72509-76-3
Jingsj CID: J-44486-6
Molecular Formula: C₁₈H₁₉Cl₂NO₄
Chinese Name: 非洛地平
Molecular Weight: 384.254 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	142-145°C
Boiling Point	471.5±45.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	239.0±28.7 °C
Exact Mass	383.069122
PSA	64.63000
LogP	4.83
Vapor Pressure	0.0±1.2 mmHg at 25°C
Refractive Index	1.550
Additional Property	insoluble

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Additional Information	[1]. Johnson, J.D. and D.A. Fugman, Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segments. J Pharmacol Exp Ther, 1983. 226(2): p. 330-4. [2]. Rodler, S., et al., Ca(2+)-channel blockers modulate the expression of interleukin-6 and interleukin-8 genes in human vascular smooth muscle cells. J Mol Cell Cardiol, 1995. 27(10): p. 2295-302. [3]. Yiu, S. and E.E. Knaus, Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system. J Med Chem, 1996. 39(23): p. 4576-82.

Additional Information

[1]. Johnson, J.D. and D.A. Fugman, Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segments. J Pharmacol Exp Ther, 1983. 226(2): p. 330-4. [2]. Rodler, S., et al., Ca(2+)-channel blockers modulate the expression of interleukin-6 and interleukin-8 genes in human vascular smooth muscle cells. J Mol Cell Cardiol, 1995. 27(10): p. 2295-302. [3]. Yiu, S. and E.E. Knaus, Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system. J Med Chem, 1996. 39(23): p. 4576-82.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Felodipine?

The CAS number of Felodipine is 72509-76-3.

What are the molecular formula and molecular weight of Felodipine?

Felodipine has molecular formula C18H19Cl2NO4 and molecular weight 384.254 g/mol.

Is Felodipine hazardous?

Felodipine has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

What are the upstream and downstream products of Felodipine?

For Felodipine, Upstream Products: Methyl (Z)-3-aminocrotonate, Sodium methoxide, Ethyl (2Z)-3-amino-2-butenoate; Downstream Products: Dehydro Felodipine.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Felodipine (CAS 72509-76-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-44486-6 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.