Strophanthidin

毒毛旋花子苷元

Also known as: Card-20(22)-enolide,3,5,14-trihydroxy-19-oxo-, (3β,5β)-, 3β,5,14-Trihydroxy-19-oxo-5β,20(22)-cardenolide, (3S,5S,8R,9S,10S,13R,14S,17R)-3,5,14-trihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde, Convallatoxigenin, Corchorin, Corchoside A aglycon, k-Strophanthidin, Strophanthidine, EINECS 200-626-6, MFCD00046266

Strophanthidin (CAS 66-28-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C23H32O6 and a molecular weight of 404.49700 g/mol. It is also known as Card-20(22)-enolide,3,5,14-trihydroxy-19-oxo-, (3β,5β)-, 3β,5,14-Trihydroxy-19-oxo-5β,20(22)-cardenolide and (3S,5S,8R,9S,10S,13R,14S,17R)-3,5,14-trihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde. Key properties include a melting point of 169ºC, a boiling point of 620.7ºC at 760 mmHg, a density of 1.432 g/cm3 and a flash point of 214.9ºC. It is classified under GHS with signal word Danger and hazard statements H300, H310 and H330 — Fatal if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 66-28-4
Jingsj CID: J-31557-1
Molecular Formula: C₂₃H₃₂O₆
Chinese Name: 毒毛旋花子苷元
Molecular Weight: 404.49700 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	169ºC
Boiling Point	620.7ºC at 760 mmHg
Density	1.432 g/cm3
Flash Point	214.9ºC
Exact Mass	404.22000
PSA	104.06000
LogP	1.89820
Refractive Index	1.674

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H300
H310
H330 — Fatal if inhaled

Activity & Biological Data

Target	Na+/K+-ATPase[2]
Additional Information	[1]. Reddy D, et al. Strophanthidin Attenuates MAPK, PI3K/AKT/mTOR, and Wnt/β-Catenin Signaling Pathways in Human Cancers. Front Oncol. 2020;9:1469. Published 2020 Jan 17. [2]. Su SW, et al. Relationship between cardiotonic effects and inhibition on cardiac sarcolemmal Na+,K+-ATPase of strophan-thidin at low concentrations. Acta Pharmacol Sin. 2003;24(11):1103-1107. [3]. Bennett DL, et al. Strophanthidin-induced gain of Ca2+ occurs during diastole and not systole in guinea-pig ventricular myocytes. Pflugers Arch. 1999;437(5):731-736.

Target

Na+/K+-ATPase[2]

Additional Information

[1]. Reddy D, et al. Strophanthidin Attenuates MAPK, PI3K/AKT/mTOR, and Wnt/β-Catenin Signaling Pathways in Human Cancers. Front Oncol. 2020;9:1469. Published 2020 Jan 17. [2]. Su SW, et al. Relationship between cardiotonic effects and inhibition on cardiac sarcolemmal Na+,K+-ATPase of strophan-thidin at low concentrations. Acta Pharmacol Sin. 2003;24(11):1103-1107. [3]. Bennett DL, et al. Strophanthidin-induced gain of Ca2+ occurs during diastole and not systole in guinea-pig ventricular myocytes. Pflugers Arch. 1999;437(5):731-736.

Frequently Asked Questions

What is the CAS number of Strophanthidin?

The CAS number of Strophanthidin is 66-28-4.

What are the molecular formula and molecular weight of Strophanthidin?

Strophanthidin has molecular formula C23H32O6 and molecular weight 404.49700 g/mol.

Is Strophanthidin hazardous?

Strophanthidin has GHS signal word Danger and hazard statements H300; H310; H330 — Fatal if inhaled.

What are the upstream and downstream products of Strophanthidin?

For Strophanthidin, Upstream Products: Cymarin; Downstream Products: Convallatoxin.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Strophanthidin (CAS 66-28-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-31557-1 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.