Ketoconazole

Also known as: Nizoral, R-41400, 1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, Fungoral, Fungarest, Ketoderm, Ketoisdin, Nizral, Brizoral, Fitonal, Onofin K, Orifungal M, Panfungol, kw-1414

Ketoconazole (CAS 65277-42-1) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C26H28Cl2N4O4 and a molecular weight of 531.431 g/mol. Key properties include a melting point of 146°C, a boiling point of 753.4±60.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 409.4±32.9 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed, H373 — May cause damage to organs through prolonged exposure and H410 — Very toxic to aquatic life with long lasting effects. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 65277-42-1
Jingsj CID: J-1099331-6
Molecular Formula: C₂₆H₂₈Cl₂N₄O₄
Molecular Weight: 531.431 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	146°C
Boiling Point	753.4±60.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	409.4±32.9 °C
Exact Mass	530.148743
PSA	69.06000
LogP	3.55
Vapor Pressure	0.0±2.5 mmHg at 25°C
Refractive Index	1.642

GHS Safety & Compliance

Acute Toxicity / Health Hazard / Environmental HazardSignal word: Danger

H301 — Toxic if swallowed
H373 — May cause damage to organs through prolonged exposure
H410 — Very toxic to aquatic life with long lasting effects

Activity & Biological Data

Additional Information	[1]. Seif El-Din SH, et al. Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice. Korean J Parasitol. 2013 Apr;51(2):165-75. [2]. Eil C. Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24(8):367-70. [3]. Muindi JR et al. CYP24A1 inhibition enhances the antitumor activity of calcitriol. Endocrinology. 2010 Sep;151(9):4301-12.

Additional Information

[1]. Seif El-Din SH, et al. Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice. Korean J Parasitol. 2013 Apr;51(2):165-75. [2]. Eil C. Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24(8):367-70. [3]. Muindi JR et al. CYP24A1 inhibition enhances the antitumor activity of calcitriol. Endocrinology. 2010 Sep;151(9):4301-12.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Ketoconazole?

The CAS number of Ketoconazole is 65277-42-1.

What are the molecular formula and molecular weight of Ketoconazole?

Ketoconazole has molecular formula C26H28Cl2N4O4 and molecular weight 531.431 g/mol.

Is Ketoconazole hazardous?

Ketoconazole has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H373 — May cause damage to organs through prolonged exposure; H410 — Very toxic to aquatic life with long lasting effects.

What are the upstream and downstream products of Ketoconazole?

For Ketoconazole, Upstream Products: Imidazole, 1-(4-Hydroxyphenyl)piperazine, 1-Acetyl-4-(4-hydroxyphenyl)piperazine; Downstream Products: Minoxidil.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Ketoconazole (CAS 65277-42-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1099331-6 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.