Oltipraz

Also known as: RP 35972, NSC 347901, 4-Methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione, 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione

Oltipraz (CAS 64224-21-1) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C8H6N2S3 and a molecular weight of 226.342 g/mol. Key properties include a melting point of 165-166ºC, a boiling point of 408.1±55.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 200.6±31.5 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 64224-21-1
Jingsj CID: J-15344-7
Molecular Formula: C₈H₆N₂S₃
Molecular Weight: 226.342 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	165-166ºC
Boiling Point	408.1±55.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	200.6±31.5 °C
Exact Mass	225.969315
PSA	114.35000
LogP	1.92
Vapor Pressure	0.0±0.9 mmHg at 25°C
Refractive Index	1.760
Storage Conditions	2-8°C

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Additional Information	[1]. Lee WH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Mol Cancer Ther. 2009 Oct;8(10):2791-802. [2]. Ramos-Gomez M, et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5. [3]. Lv S, et al. Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism. J Endocrinol. 2017 Aug;234(2):73-87.

Additional Information

[1]. Lee WH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Mol Cancer Ther. 2009 Oct;8(10):2791-802. [2]. Ramos-Gomez M, et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5. [3]. Lv S, et al. Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism. J Endocrinol. 2017 Aug;234(2):73-87.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Oltipraz?

The CAS number of Oltipraz is 64224-21-1.

What are the molecular formula and molecular weight of Oltipraz?

Oltipraz has molecular formula C8H6N2S3 and molecular weight 226.342 g/mol.

Is Oltipraz hazardous?

Oltipraz has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

What are the upstream and downstream products of Oltipraz?

For Oltipraz, Upstream Products: Carbon.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Oltipraz (CAS 64224-21-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-15344-7 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.