Cyclosporin A
环孢霉素A
Also known as: Cyclosporine A, Ciclosporin A, CsA, Sandimmune, Neoral, Restasis, Optimmune, Sandimmun, Cipol N, Neoplanta, Antibiotic S 7481F1, cyclosporin, ciclosporin
Cyclosporin A (CAS 59865-13-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C62H111N11O12 and a molecular weight of 1202.611 g/mol. It is also known as Cyclosporine A, Ciclosporin A and CsA. Key properties include a melting point of 148-151°C, a boiling point of 1293.8±65.0 °C at 760 mmHg, a density of 1.0±0.1 g/cm3 and a flash point of 736.3±34.3 °C. It is classified under GHS with signal word Danger and hazard statements H302 — Harmful if swallowed, H350 — May cause cancer and H360 — May damage fertility or the unborn child. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 59865-13-3
- Jingsj CID
- J-18599-2
- Molecular Formula
- C62H111N11O12
- Chinese Name
- 环孢霉素A
- Molecular Weight
- 1202.611 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 148-151°C |
|---|---|
| Boiling Point | 1293.8±65.0 °C at 760 mmHg |
| Density | 1.0±0.1 g/cm3 |
| Flash Point | 736.3±34.3 °C |
| Exact Mass | 1201.841309 |
| PSA | 278.80000 |
| LogP | 3.35 |
| Vapor Pressure | 0.0±0.6 mmHg at 25°C |
| Refractive Index | 1.468 |
| Storage Conditions | 2-8℃ |
| Additional Property | ethanol: 30 mg/mL |
GHS Safety & Compliance
- H302 — Harmful if swallowed
- H350 — May cause cancer
- H360 — May damage fertility or the unborn child
Activity & Biological Data
| Target | IC50: 7 nM (calcineurin) |
|---|---|
| Additional Information | [1]. Handschumacher RE, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984 Nov 2;226(4674):544-7. [2]. Liu J, et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991 Aug 23;66(4):807-15. [3]. Fruman DA, et al. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci U S A. 1992 May 1;89(9):3686-90. [4]. Flanagan WM, et al. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature. 1991 Aug 29;352(6338):803-7. [5]. Nicolli A, et al. Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel. J Biol Chem. 1996 Jan 26;271(4):2185-92. [6]. Borel JF, et al. Effects of the new anti-lymphocytic peptide cyclosporin A in animals. Immunology. 1977 Jun;32(6):1017-25. [7]. Williams, R, et al. Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. European FK506 Multicentre Liver Study Group. Lancet, 1994, 344(8920), 423-428. |
Customs & Trade Information
| HS Code | 2941909000 |
|---|
Frequently Asked Questions
What is the CAS number of Cyclosporin A?
The CAS number of Cyclosporin A is 59865-13-3.
What are the molecular formula and molecular weight of Cyclosporin A?
Cyclosporin A has molecular formula C62H111N11O12 and molecular weight 1202.611 g/mol.
Is Cyclosporin A hazardous?
Cyclosporin A has GHS signal word Danger and hazard statements H302 — Harmful if swallowed; H350 — May cause cancer; H360 — May damage fertility or the unborn child.
What are the upstream and downstream products of Cyclosporin A?
For Cyclosporin A, Downstream Products: Dihydrocyclosporin A.
Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Cyclosporin A (CAS 59865-13-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-18599-2 (accessed 2026-10-28).
Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.