Trichostatin A
曲古柳菌素A
Also known as: TSA, (R)-Trichostatin A, (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide, 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-, 7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide
Trichostatin A (CAS 58880-19-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C17H22N2O3 and a molecular weight of 302.368 g/mol. It is also known as TSA, (R)-Trichostatin A and (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide. Key properties include a melting point of 141-143ºC and a density of 1.1±0.1 g/cm3. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed, H312 — Harmful in contact with skin and H332 — Harmful if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 58880-19-6
- Jingsj CID
- J-20282-4
- Molecular Formula
- C17H22N2O3
- Chinese Name
- 曲古柳菌素A
- Molecular Weight
- 302.368 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 141-143ºC |
|---|---|
| Density | 1.1±0.1 g/cm3 |
| Exact Mass | 302.163055 |
| PSA | 69.64000 |
| LogP | 2.77 |
| Refractive Index | 1.578 |
| Storage Conditions | -20℃ |
GHS Safety & Compliance
- H302 — Harmful if swallowed
- H312 — Harmful in contact with skin
- H332 — Harmful if inhaled
- H315 — Causes skin irritation
- H317 — May cause an allergic skin reaction
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Target | HDAC:1.8 nM (IC50) |
|---|---|
| Additional Information | [1]. Vigushin DM et al. Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin Cancer Res. 2001 Apr;7(4):971-6. [2]. Karolczak-Bayatti M, et al. Expression of the GTP-Binding Protein Gαs in Human Myometrial Cells is Regulated by Ubiquitination and Protein Degradation: Involvement of Proteasomal Inhibition by Trichostatin A.,Reprod Sci. 2012 Aug 8. [3]. Hu X, et al. Histone deacetylase inhibitor trichostatin A promotes the osteogenic differentiation of rat adipose-derived stem cells by altering the epigenetic modifications on Runx2 promoter in a BMP signaling-dependent manner.,Stem Cells Dev. 2012 Aug 8. [4]. Azechi T, et al. Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. J Atheroscler Thromb. 2013;20(6):538-47. |
Customs & Trade Information
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Frequently Asked Questions
What is the CAS number of Trichostatin A?
The CAS number of Trichostatin A is 58880-19-6.
What are the molecular formula and molecular weight of Trichostatin A?
Trichostatin A has molecular formula C17H22N2O3 and molecular weight 302.368 g/mol.
Is Trichostatin A hazardous?
Trichostatin A has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H312 — Harmful in contact with skin; H332 — Harmful if inhaled.
What are the upstream and downstream products of Trichostatin A?
For Trichostatin A, Upstream Products: 4-Dimethylaminobenzaldehyde.
Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Trichostatin A (CAS 58880-19-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-20282-4 (accessed 2026-10-28).
Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.