Azelastine

氮卓斯汀

Also known as: Azelastine, 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one, 4-(p-Chlorobenzyl)-2-(N-methylperhydroazepin-4-yl)-1(2H)-phthalazinone, 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone, Allergodil, Rhinolast, Optilast, Astelin, UNII:ZQI909440X

Azelastine (CAS 58581-89-8) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H24ClN3O and a molecular weight of 381.898 g/mol. It is also known as 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one, 4-(p-Chlorobenzyl)-2-(N-methylperhydroazepin-4-yl)-1(2H)-phthalazinone and 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone. Key properties include a boiling point of 533.9±60.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 276.7±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 58581-89-8
Jingsj CID: J-47522-0
Molecular Formula: C₂₂H₂₄ClN₃O
Chinese Name: 氮卓斯汀
Molecular Weight: 381.898 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

No offers for this compound yet.

Request a quote

Physicochemical Properties

Boiling Point	533.9±60.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	276.7±32.9 °C
Exact Mass	381.160797
PSA	38.13000
LogP	3.71
Vapor Pressure	0.0±1.4 mmHg at 25°C
Refractive Index	1.642

Activity & Biological Data

Additional Information	[1]. Kempuraj, D., et al., Azelastine is more potent than olopatadine n inhibiting interleukin-6 and tryptase release from human umbilical cord blood-derived cultured mast cells. Ann Allergy Asthma Immunol, 2002. 88(5): p. 501-6. [2]. Canonica, G.W., et al., Topical azelastine in perennial allergic conjunctivitis. Curr Med Res Opin, 2003. 19(4): p. 321-9. [3]. Lieberman, P., M.A. Kaliner, and W.J. Wheeler, Open-label evaluation of azelastine nasal spray in patients with seasonal allergic rhinitis and nonallergic vasomotor rhinitis. Curr Med Res Opin, 2005. 21(4): p. 611-8.

Additional Information

[1]. Kempuraj, D., et al., Azelastine is more potent than olopatadine n inhibiting interleukin-6 and tryptase release from human umbilical cord blood-derived cultured mast cells. Ann Allergy Asthma Immunol, 2002. 88(5): p. 501-6. [2]. Canonica, G.W., et al., Topical azelastine in perennial allergic conjunctivitis. Curr Med Res Opin, 2003. 19(4): p. 321-9. [3]. Lieberman, P., M.A. Kaliner, and W.J. Wheeler, Open-label evaluation of azelastine nasal spray in patients with seasonal allergic rhinitis and nonallergic vasomotor rhinitis. Curr Med Res Opin, 2005. 21(4): p. 611-8.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Azelastine?

The CAS number of Azelastine is 58581-89-8.

What are the molecular formula and molecular weight of Azelastine?

Azelastine has molecular formula C22H24ClN3O and molecular weight 381.898 g/mol.

What are the upstream and downstream products of Azelastine?

For Azelastine, Upstream Products: 4-Chlorophenylacetic acid, Phthalic anhydride, 1-methylazepan-4-one.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Azelastine (CAS 58581-89-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-47522-0 (accessed 2026-10-29).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.