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Promethazine Hydrochloride

Also known as: 10-(2-Dimethylamino-1-propyl)phenothiazine Hydrochloride, 10-[2-(Dimethylamino)propyl]phenothiazine Hydrochloride, N,N,alpha-Trimethyl-10H-phenothiazine-10-ethanamine Hydrochloride, Phenergan, Protazine, Thiergan, Genphen, (±)-Promethazine Hydrochloride, 10-(2-Dimethylamino-2-methylethyl)phenothiazine Hydrochloride, N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine Hydrochloride

Promethazine Hydrochloride (CAS 58-33-3) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C17H21ClN2S and a molecular weight of 320.880 g/mol. Key properties include a melting point of 230-232°C, a boiling point of 403.7ºC at 760 mmHg, a density of 1.131 g/cm3 and a flash point of 198ºC. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed, H332 — Harmful if inhaled and H315 — Causes skin irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.
58-33-3
Jingsj CID
J-32938-4
Molecular Formula
C17H21ClN2S
Molecular Weight
320.880 g/mol
Category
Organic Acids
Last updated
8/21/2026
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Physicochemical Properties

Melting Point230-232°C
Boiling Point403.7ºC at 760 mmHg
Density1.131 g/cm3
Flash Point198ºC
Exact Mass320.111389
PSA31.78000
LogP5.10640
Storage ConditionsRefrigerator

GHS Safety & Compliance

Irritant / Environmental HazardSignal word: Warning
  • H302 — Harmful if swallowed
  • H332 — Harmful if inhaled
  • H315 — Causes skin irritation
  • H317 — May cause an allergic skin reaction
  • H319 — Causes serious eye irritation
  • H335 — May cause respiratory irritation
  • H411 — Toxic to aquatic life with long lasting effects

Activity & Biological Data

Additional Information[1]. Strenkoski-Nix LC, et al. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am J Health Syst Pharm. 2000 Aug 15;57(16):1499-505. [2]. Fiorella D, et al. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl). 1995 Oct;121(3):347-56. [3]. Seeman P, et al. Dopamine D2 receptor binding sites for agonists. A tetrahedral model. Mol Pharmacol. 1985 Nov;28(5):391-9. [4]. Burt DR, et al. Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science. 1977 Apr 15;196(4287):326-8.

Customs & Trade Information

HS Code2933699090
Summary2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Promethazine Hydrochloride?

The CAS number of Promethazine Hydrochloride is 58-33-3.

What are the molecular formula and molecular weight of Promethazine Hydrochloride?

Promethazine Hydrochloride has molecular formula C17H21ClN2S and molecular weight 320.880 g/mol.

Is Promethazine Hydrochloride hazardous?

Promethazine Hydrochloride has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H332 — Harmful if inhaled; H315 — Causes skin irritation.

What are the upstream and downstream products of Promethazine Hydrochloride?

For Promethazine Hydrochloride, Downstream Products: Promethazine, Promethazine sulfoxide, thiazinamium metilsulfate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "Promethazine Hydrochloride (CAS 58-33-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-32938-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.