Pyrimethamine
Also known as: 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine, 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine, Daraprim, Malocide, Chloridine, Pirimetamin, RP 4753, BW 50-63
Pyrimethamine (CAS 58-14-0) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C12H13ClN4 and a molecular weight of 248.711 g/mol. Key properties include a melting point of 233-234°C, a boiling point of 368.4±52.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 176.6±30.7 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 58-14-0
- Jingsj CID
- J-19055-0
- Molecular Formula
- C12H13ClN4
- Molecular Weight
- 248.711 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 233-234°C |
|---|---|
| Boiling Point | 368.4±52.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 176.6±30.7 °C |
| Exact Mass | 248.082870 |
| PSA | 77.82000 |
| LogP | 1.03 |
| Vapor Pressure | 0.0±0.8 mmHg at 25°C |
| Refractive Index | 1.667 |
| Storage Conditions | 0-6°C |
| Stability | Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents. |
| Additional Property | <0.01 g/100 mL at 21 ºC |
GHS Safety & Compliance
- H302 — Harmful if swallowed
Activity & Biological Data
| Additional Information | [1]. Basco LK, et al. In vitro activity of pyrimethamine, cycloguanil, and other antimalarial drugs against African isolates and clones of Plasmodium falciparum. Am J Trop Med Hyg. 1994 Feb; 50(2):193-9. [2]. Inceboz T, et al. Preparation of (131)I-Pyrimethamine and evaluation for scintigraphy of experimentally Toxoplasma gondii-infectedrats. J Drug Target. 2013 Feb;21(2):175-9. [3]. Wright PD, et al. Screening for inhibitors of the SOD1 gene promoter: pyrimethamine does not reduce SOD1 levels in cell and animal models. Neurosci Lett. 2010 Oct 4;482(3):188-92. [4]. Martins-Duarte ES, et al. Toxoplasma gondii: the effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model. Exp Parasitol. 2013 Mar;133(3):294-9. [5]. Taylor WR, et al. Antimalarial drug toxicity: a review. Drug Saf. 2004;27(1):25-61. |
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Customs & Trade Information
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Pyrimethamine?
The CAS number of Pyrimethamine is 58-14-0.
What are the molecular formula and molecular weight of Pyrimethamine?
Pyrimethamine has molecular formula C12H13ClN4 and molecular weight 248.711 g/mol.
Is Pyrimethamine hazardous?
Pyrimethamine has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.
What are the upstream and downstream products of Pyrimethamine?
For Pyrimethamine, Upstream Products: 4-Chlorobenzyl cyanide, (4-Chlorophenyl)boronic acid, Diazomethane.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Pyrimethamine (CAS 58-14-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-19055-0 (accessed 2026-11-07).
Data for reference only; verify product details with suppliers before purchase.