Domperidone

Also known as: Motilium, 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolyl)propyl]-4-piperidyl]benzimidazol-2-one, 5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one, 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one, Domperidone base, KW-5338, R-33812

Domperidone (CAS 57808-66-9) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C22H24ClN5O2 and a molecular weight of 425.911 g/mol. Key properties include a melting point of 242.5ºC, a boiling point of 723.6±70.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 391.4±35.7 °C. It is classified under GHS with signal word Warning and hazard statements H361 — Suspected of damaging fertility or the unborn child. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 57808-66-9
Jingsj CID: J-1319989-8
Molecular Formula: C₂₂H₂₄ClN₅O₂
Molecular Weight: 425.911 g/mol
Category: Ketones
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	242.5ºC
Boiling Point	723.6±70.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	391.4±35.7 °C
Exact Mass	425.161865
PSA	78.82000
LogP	4.63
Vapor Pressure	0.0±2.4 mmHg at 25°C
Refractive Index	1.729
Additional Property	DMSO: >10 mg/mL

GHS Safety & Compliance

Health HazardSignal word: Warning

H361 — Suspected of damaging fertility or the unborn child

Activity & Biological Data

Additional Information	[1]. Parkman, H.P., et al., Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects. Dig Dis Sci, 2011. 56(1): p. 115-24. [2]. Ali, I., et al., Screening of domperidone in wastewater by high performance liquid chromatography and solid phase extraction methods. Talanta, 2006. 68(3): p. 928-31. [3]. Lertxundi, U., et al., Domperidone in Parkinson's disease: a perilous arrhythmogenic or the gold standard. Curr Drug Saf, 2013. 8(1): p. 63-8.

Additional Information

[1]. Parkman, H.P., et al., Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects. Dig Dis Sci, 2011. 56(1): p. 115-24. [2]. Ali, I., et al., Screening of domperidone in wastewater by high performance liquid chromatography and solid phase extraction methods. Talanta, 2006. 68(3): p. 928-31. [3]. Lertxundi, U., et al., Domperidone in Parkinson's disease: a perilous arrhythmogenic or the gold standard. Curr Drug Saf, 2013. 8(1): p. 63-8.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Domperidone?

The CAS number of Domperidone is 57808-66-9.

What are the molecular formula and molecular weight of Domperidone?

Domperidone has molecular formula C22H24ClN5O2 and molecular weight 425.911 g/mol.

Is Domperidone hazardous?

Domperidone has GHS signal word Warning and hazard statements H361 — Suspected of damaging fertility or the unborn child.

What are the upstream and downstream products of Domperidone?

For Domperidone, Upstream Products: 4-Methyl-2-pentanone, 1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one, 5-Chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Domperidone (CAS 57808-66-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1319989-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.