Fenobam

非诺班

Also known as: Fenobam, 1-(3-Chlorophenyl)-3-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea, 1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea, Mcn-3377, N-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea, N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea, N-3-chlorophenyl-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea, [3H]-Fenobam

Fenobam (CAS 57653-26-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C11H11ClN4O2 and a molecular weight of 266.68400 g/mol. It is also known as 1-(3-Chlorophenyl)-3-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea, 1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea and Mcn-3377. Key property: a density of 1.47 g/cm3. It is classified under GHS with signal word Danger and hazard statements H300. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 57653-26-6
Jingsj CID: J-1981100-0
Molecular Formula: C₁₁H₁₁ClN₄O₂
Chinese Name: 非诺班
Molecular Weight: 266.68400 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.47 g/cm3
Exact Mass	266.05700
PSA	73.80000
LogP	1.12690
Refractive Index	1.668
Storage Conditions	2-8°C

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H300

Activity & Biological Data

Target	rat mGluR5:54 nM (Kd) human mGluR5:31 nM (Kd)
Additional Information	[1]. Porter RH, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 2005 Nov;315(2):711-21. [2]. Laura F, et al. The Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Fenobam: Pharmacokinetics, Side Effects, and Analgesic Effects in Healthy Human Subjects.bioRxiv 391383;

Target

rat mGluR5:54 nM (Kd) human mGluR5:31 nM (Kd)

Additional Information

[1]. Porter RH, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 2005 Nov;315(2):711-21. [2]. Laura F, et al. The Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Fenobam: Pharmacokinetics, Side Effects, and Analgesic Effects in Healthy Human Subjects.bioRxiv 391383;

Frequently Asked Questions

What is the CAS number of Fenobam?

The CAS number of Fenobam is 57653-26-6.

What are the molecular formula and molecular weight of Fenobam?

Fenobam has molecular formula C11H11ClN4O2 and molecular weight 266.68400 g/mol.

Is Fenobam hazardous?

Fenobam has GHS signal word Danger and hazard statements H300.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Fenobam (CAS 57653-26-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1981100-0 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.