Costunolide

Also known as: (+)-Costunolide, Costus lactone, (3aS,6E,10E,11aR)-6,10-Dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one, (3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylenecyclodeca[b]furan-2(3H)-one, NSC 106404, NSC-106404, Germacra-1(10),4,11(13)-trien-12-oic acid, 6α-hydroxy-, γ-lactone, (E,E)-, Costundide, Costunlide, Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-, (3aS,6E,10E,11aR)-, MFCD00210262

Costunolide (CAS 553-21-9) is a compound in the Esters category listed in the Jingsj chemical database. It has the molecular formula C15H20O2 and a molecular weight of 232.318 g/mol. Key properties include a melting point of 106 °C, a boiling point of 385.4±42.0 °C at 760 mmHg, a density of 1.0±0.1 g/cm3 and a flash point of 162.0±25.3 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H317 — May cause an allergic skin reaction and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 553-21-9
Jingsj CID: J-18810-8
Molecular Formula: C₁₅H₂₀O₂
Molecular Weight: 232.318 g/mol
Category: Esters
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	106 °C
Boiling Point	385.4±42.0 °C at 760 mmHg
Density	1.0±0.1 g/cm3
Flash Point	162.0±25.3 °C
Exact Mass	232.146332
PSA	26.30000
LogP	4.05
Vapor Pressure	0.0±0.9 mmHg at 25°C
Refractive Index	1.519
Storage Conditions	Store at -20°C

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H317 — May cause an allergic skin reaction
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Additional Information	[1]. Cheon YH, Song MJ, Kim JY, Costunolide Inhibits Osteoclast Differentiation by Suppressing c-Fos Transcriptional Activity. Phytother Res. 2013 Jul 6. [2]. Rasul A, Bao R, Malhi M, Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction. Molecules. 2013 Jan 24;18(2):1418-33. [3]. Kretschmer N, Rinner B, Stuendl N, Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells. Planta Med. 2012 Nov;78(16):1749-56. [4]. Matsuda H, Shimoda H, Ninomiya K, Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, on blood-ethanol elevation in rats: involvement of inhibition of gastric emptying and increase in gastric juice secretion. Alcohol Alcohol. 2002 Mar-Apr;37(2):121-7.

Additional Information

[1]. Cheon YH, Song MJ, Kim JY, Costunolide Inhibits Osteoclast Differentiation by Suppressing c-Fos Transcriptional Activity. Phytother Res. 2013 Jul 6. [2]. Rasul A, Bao R, Malhi M, Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction. Molecules. 2013 Jan 24;18(2):1418-33. [3]. Kretschmer N, Rinner B, Stuendl N, Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells. Planta Med. 2012 Nov;78(16):1749-56. [4]. Matsuda H, Shimoda H, Ninomiya K, Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, on blood-ethanol elevation in rats: involvement of inhibition of gastric emptying and increase in gastric juice secretion. Alcohol Alcohol. 2002 Mar-Apr;37(2):121-7.

Frequently Asked Questions

What is the CAS number of Costunolide?

The CAS number of Costunolide is 553-21-9.

What are the molecular formula and molecular weight of Costunolide?

Costunolide has molecular formula C15H20O2 and molecular weight 232.318 g/mol.

Is Costunolide hazardous?

Costunolide has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H317 — May cause an allergic skin reaction; H319 — Causes serious eye irritation.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Costunolide (CAS 553-21-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-18810-8 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.