Nutlin-3

Also known as: (±)-Nutlin-3, Nutlin-3 (racemic), 4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one, rel-4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]piperazin-2-one, MDM2 antagonist Nutlin-3, MFCD07784509

Nutlin-3 (CAS 548472-68-0) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C30H30Cl2N4O4 and a molecular weight of 581.490 g/mol. It is also known as (±)-Nutlin-3, Nutlin-3 (racemic) and 4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one. Key property: a density of 1.4±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 548472-68-0
Jingsj CID: J-11037-2
Molecular Formula: C₃₀H₃₀Cl₂N₄O₄
Molecular Weight: 581.490 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

No offers for this compound yet.

Request a quote

Physicochemical Properties

Density	1.4±0.1 g/cm3
Exact Mass	580.164429
PSA	83.47000
LogP	2.77
Refractive Index	1.648

Activity & Biological Data

Target	Ki: 90 nM (p53-MDM2)[1]
Additional Information	[1]. Yu Z, et al. Design, synthesis and biological evaluation of sulfamide and triazole benzodiazepines as novel p53-MDM2 inhibitors. Int J Mol Sci. 2014 Sep 5;15(9):15741-53. [2]. Zhang Y, et al. Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth.Cancer Biol Ther. Cancer Biol Ther. 2012 Aug;13(10):915-24. [3]. Supiot S, et al. Nutlin-3 radiosensitizes hypoxic prostate cancer cells independent of p53. Mol Cancer Ther. 2008 Apr;7(4):993-9.

Target

Ki: 90 nM (p53-MDM2)[1]

Additional Information

[1]. Yu Z, et al. Design, synthesis and biological evaluation of sulfamide and triazole benzodiazepines as novel p53-MDM2 inhibitors. Int J Mol Sci. 2014 Sep 5;15(9):15741-53. [2]. Zhang Y, et al. Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth.Cancer Biol Ther. Cancer Biol Ther. 2012 Aug;13(10):915-24. [3]. Supiot S, et al. Nutlin-3 radiosensitizes hypoxic prostate cancer cells independent of p53. Mol Cancer Ther. 2008 Apr;7(4):993-9.

Frequently Asked Questions

What is the CAS number of Nutlin-3?

The CAS number of Nutlin-3 is 548472-68-0.

What are the molecular formula and molecular weight of Nutlin-3?

Nutlin-3 has molecular formula C30H30Cl2N4O4 and molecular weight 581.490 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Nutlin-3 (CAS 548472-68-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-11037-2 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.