Conessine
地麻素
Also known as: Conessin, Wrightine, NERIINE, NERVINE, ROGUESSINE, ROQUESSINE, WRIGHTINE, NSC 119994, Konessin, (3β)-N,N-Dimethylcon-5-enin-3-amine, 3β-(Dimethylamino)con-5-enine, 3-beta-(dimethylamino)-con-5-enin, n,18-dihydrotrimethyl-conkurchin, n-dimethyl-(3-beta)-con-5-enin-3-amin, Con-5-enin-3-amine, N,N-dimethyl-, (3β)-
Conessine (CAS 546-06-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C24H40N2 and a molecular weight of 356.588 g/mol. It is also known as Conessin, Wrightine and NERIINE. Key properties include a melting point of 126-127ºC, a boiling point of 450.4±45.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 199.6±16.5 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 546-06-5
- Jingsj CID
- J-45989-5
- Molecular Formula
- C24H40N2
- Chinese Name
- 地麻素
- Molecular Weight
- 356.588 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 126-127ºC |
|---|---|
| Boiling Point | 450.4±45.0 °C at 760 mmHg |
| Density | 1.1±0.1 g/cm3 |
| Flash Point | 199.6±16.5 °C |
| Exact Mass | 356.319153 |
| PSA | 6.48000 |
| LogP | 5.71 |
| Vapor Pressure | 0.0±1.1 mmHg at 25°C |
| Refractive Index | 1.564 |
GHS Safety & Compliance
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Target | H3 Receptor:5.4 nM (Ki) rat H3 receptor:25 nM (Ki) Guinea pig H3 Receptor:6.0 nM (Ki) Dog H3 Receptor:5.7 nM (Ki) |
|---|---|
| Additional Information | [1]. Santora VJ, et al. A new family of H3 receptor antagonists based on the natural product Conessine. Bioorg Med Chem Lett. 2008;18(4):1490-1494. [2]. Kim H, et al. Conessine treatment reduces dexamethasone-induced muscle atrophy by regulating MuRF1 and atrogin-1 expression [published online ahead of print, 2018 Feb 1]. J Microbiol Biotechnol. 2018;10.4014.jmb.1711.11009. |
Frequently Asked Questions
What is the CAS number of Conessine?
The CAS number of Conessine is 546-06-5.
What are the molecular formula and molecular weight of Conessine?
Conessine has molecular formula C24H40N2 and molecular weight 356.588 g/mol.
Is Conessine hazardous?
Conessine has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.
Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Conessine (CAS 546-06-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-45989-5 (accessed 2026-10-28).
Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.