Indometacin

Also known as: Indomethacin, 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic Acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetic acid, 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid, Indocin, INDOCIN, INDOMETACIN, INDOMETACINE, Amuno, Bonidin, Catlep, Dolovin, Inacid, Indacin, Lausit, Tannex, Vonum

Indometacin (CAS 53-86-1) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C19H16ClNO4 and a molecular weight of 357.78800 g/mol. Key properties include a melting point of 155-162 °C, a boiling point of 499.4ºC at 760 mmHg, a density of 1.32g/cm3 and a flash point of 255.8ºC. It is classified under GHS with signal word Danger and hazard statements H300. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 53-86-1
Jingsj CID: J-37843-5
Molecular Formula: C₁₉H₁₆ClNO₄
Molecular Weight: 357.78800 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	155-162 °C
Boiling Point	499.4ºC at 760 mmHg
Density	1.32g/cm3
Flash Point	255.8ºC
Exact Mass	357.07700
PSA	68.53000
LogP	3.92730
Stability	Stable. Incompatible with strong oxidizing agents.
Additional Property	ethanol: 50 mg/mL, clear, yellow-green

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H300

Activity & Biological Data

Target	Human COX-1:18 nM (IC50, in CHO cells) Human COX-2:26 nM (IC50, in CHO cells)
Additional Information	[1]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [2]. Lopes RS, et al. Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia. J Biosci. 2016 Sep;41(3):381-94. [3]. Afroz S, et al. Concentrated phosphatidic acid in cereal brans as potential protective agents against indomethacin-induced stomach ulcer. J Agric Food Chem. 2016 Aug 26. [4]. Qixiong Zhang, et al. Structure-Property Correlations of Reactive Oxygen Species-Responsive and Hydrogen Peroxide-Eliminating Materials with Anti-Oxidant and Anti-Inflammatory Activities. Chem Mater. 2017, 29(19):8221-8238.

Target

Human COX-1:18 nM (IC50, in CHO cells) Human COX-2:26 nM (IC50, in CHO cells)

Additional Information

[1]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [2]. Lopes RS, et al. Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia. J Biosci. 2016 Sep;41(3):381-94. [3]. Afroz S, et al. Concentrated phosphatidic acid in cereal brans as potential protective agents against indomethacin-induced stomach ulcer. J Agric Food Chem. 2016 Aug 26. [4]. Qixiong Zhang, et al. Structure-Property Correlations of Reactive Oxygen Species-Responsive and Hydrogen Peroxide-Eliminating Materials with Anti-Oxidant and Anti-Inflammatory Activities. Chem Mater. 2017, 29(19):8221-8238.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Indometacin?

The CAS number of Indometacin is 53-86-1.

What are the molecular formula and molecular weight of Indometacin?

Indometacin has molecular formula C19H16ClNO4 and molecular weight 357.78800 g/mol.

Is Indometacin hazardous?

Indometacin has GHS signal word Danger and hazard statements H300.

What are the upstream and downstream products of Indometacin?

For Indometacin, Upstream Products: 4-Methoxyphenylhydrazine hydrochloride, 4-Chlorobenzoyl chloride, Levulinic acid; Downstream Products: N-(2-Phenylethyl)indomethacin Amide, Oxametacin, BML-190.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Indometacin (CAS 53-86-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-37843-5 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.