5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole
Also known as: DRB, 5,6-Dichlorobenzimidazole riboside, 5,6-Dichloro-1-β-D-ribofuranosyl-1H-benzimidazole, 1-β-D-Ribofuranosyl-5,6-dichlorobenzimidazole, NSC 401575
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (CAS 53-85-0) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C12H12Cl2N2O4 and a molecular weight of 319.141 g/mol. Key properties include a melting point of 222-224ºC, a boiling point of 606.2±65.0 °C at 760 mmHg, a density of 1.8±0.1 g/cm3 and a flash point of 320.4±34.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 53-85-0
- Jingsj CID
- J-33839-6
- Molecular Formula
- C12H12Cl2N2O4
- Molecular Weight
- 319.141 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 222-224ºC |
|---|---|
| Boiling Point | 606.2±65.0 °C at 760 mmHg |
| Density | 1.8±0.1 g/cm3 |
| Flash Point | 320.4±34.3 °C |
| Exact Mass | 318.017426 |
| PSA | 87.74000 |
| LogP | 2.05 |
| Vapor Pressure | 0.0±1.8 mmHg at 25°C |
| Refractive Index | 1.750 |
| Storage Conditions | −20°C |
| Additional Property | Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide, hot ethanol, dimethyl formamide, (1:2) dimethyl formamide:Phosphate buffer saline, water, methanol and pyridine. Slightly soluble in aqueous buffers. |
Activity & Biological Data
| Additional Information | [1]. Zandomeni RO. Kinetics of inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole on calf thymus casein kinase II. Biochem J. 1989 Sep 1;262(2):469-73. [2]. Yankulov K, et al. The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase. J Biol Chem. 1995 Oct 13;270(41):23922-5. [3]. Rickert P, et al. Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases. Oncogene. 1999 Jan 28;18(4):1093-102. [4]. Schang LM. Cyclin-dependent kinases as cellular targets for antiviral drugs. J Antimicrob Chemother. 2002 Dec;50(6):779-92. [5]. te Poele RH, et al. RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells. Oncogene. 1999 Oct 14;18(42):5765-72. |
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Frequently Asked Questions
What is the CAS number of 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole?
The CAS number of 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole is 53-85-0.
What are the molecular formula and molecular weight of 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole?
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole has molecular formula C12H12Cl2N2O4 and molecular weight 319.141 g/mol.
What are the upstream and downstream products of 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole?
For 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole, Upstream Products: 5,6-Dichloro-1H-benzo[d]imidazole, 4,5-Dichloro-1,2-benzenediamine, 5,6-dichloro-1,3-dihydro-2H-benzimidazole-2-thione.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (CAS 53-85-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-33839-6 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.