Apiole

Also known as: 1,3-Benzodioxole, 4,7-dimethoxy-5-(2-propenyl)-, 1,3-Benzodioxole,4,7-dimethoxy-5-(2-propenyl), 1-allyl-2,5-dimethoxy-3,4-methylenedioxybenzene, 1-allyl-3,4-methylenedioxy-2,5-dimethoxybenzene, 2,5-dimethoxysafrole, 3,6-dimethoxy-4,5-methylenedioxy-allylbenzene, 4,7-DIMETHOXY-5-(2-PROPENYL)-1,3-BENZODIOXOLE, 4,7-dimethoxy-5-prop-2-enyl-1,3-benzodioxole, 5-ALLYL-4,7-DIMETHOXY-1,3-BENZODIOXOLE, 5-Allyl-4,7-dimethoxy-1,3-benzodioxole, APIOL, APIOLE, Apiol, Apiole, Apioline, PARSLEY APIOLE, Parsley apiol, Parsley apiole, Parsley camphor, Petersiliencampher

Apiole (CAS 523-80-8) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C12H14O4 and a molecular weight of 222.24 g/mol. Key properties include a melting point of 29ºC, a boiling point of 294ºC, a density of 1.151g/cm3 and a flash point of 117.2ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 523-80-8
Jingsj CID: J-1984073-4
Molecular Formula: C₁₂H₁₄O₄
Molecular Weight: 222.24 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	29ºC
Boiling Point	294ºC
Density	1.151g/cm3
Flash Point	117.2ºC
Exact Mass	222.08900
PSA	36.92000
LogP	2.16100
Refractive Index	1.53

Activity & Biological Data

Additional Information	[1]. Wu KH, et al. Study of the antitumor mechanisms of apiole derivatives (AP-02) from Petroselinum crispum through induction of G0/G1 phase cell cycle arrest in human COLO 205 cancer cells. BMC Complement Altern Med. 2019 Jul 27;19(1):188. [2]. Wei PL, et al. The in vivo antitumor effects on human COLO 205 cancer cells of the 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) derivative of 5-substituted 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) isolated from the fruiting body of Antrodia camphorate. J Cancer Res Ther. 2012 Oct-Dec;8(4):532-6.

Additional Information

[1]. Wu KH, et al. Study of the antitumor mechanisms of apiole derivatives (AP-02) from Petroselinum crispum through induction of G0/G1 phase cell cycle arrest in human COLO 205 cancer cells. BMC Complement Altern Med. 2019 Jul 27;19(1):188. [2]. Wei PL, et al. The in vivo antitumor effects on human COLO 205 cancer cells of the 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) derivative of 5-substituted 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) isolated from the fruiting body of Antrodia camphorate. J Cancer Res Ther. 2012 Oct-Dec;8(4):532-6.

Customs & Trade Information

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Apiole?

The CAS number of Apiole is 523-80-8.

What are the molecular formula and molecular weight of Apiole?

Apiole has molecular formula C12H14O4 and molecular weight 222.24 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Apiole (CAS 523-80-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1984073-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.