Ethylhydrocupreine

乙氢去甲奎宁

Also known as: Optochin, Numoquin, Optoquine, Ethylhydrocuprein, Hydrocupureine ethyl ether, hydrocupreine ethyl ether, Cinchonan-9-ol,6'-ethoxy-10,11-dihydro-, (8α,9R)-, ethylhydrocupreine free base, optochine, optochin

Ethylhydrocupreine (CAS 522-60-1) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C21H28N2O2 and a molecular weight of 340.45900 g/mol. It is also known as Optochin, Numoquin and Optoquine. Key properties include a melting point of 123-128° when solvent-free, a boiling point of 508.7ºC at 760mmHg, a density of 1.18g/cm3 and a flash point of 261.5ºC. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 522-60-1
Jingsj CID: J-1958221-8
Molecular Formula: C₂₁H₂₈N₂O₂
Chinese Name: 乙氢去甲奎宁
Molecular Weight: 340.45900 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	123-128° when solvent-free
Boiling Point	508.7ºC at 760mmHg
Density	1.18g/cm3
Flash Point	261.5ºC
Exact Mass	340.21500
PSA	45.59000
LogP	3.72520
Refractive Index	1.618
Storage Conditions	2-8°C

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Target	S. pneumoniae[1] IC50: 25.75 nM (Plasmodium falciparum)[3] ggTas2r1, ggTas2r2 and ggTas2r7[4]
Additional Information	[1]. J A Kolmer, et al. CHEMOTHERAPEUTIC STUDIES WITH ETHYLHYDROCUPREINE HYDROCHLORIDE IN EXPERIMENTAL PNEUMOCOCCUS PLEURITIS. J Exp Med. 1921 May 31;33(6):693-711. [2]. Paulo R Cortes, et al. Subinhibitory Concentrations of Penicillin Increase the Mutation Rate to Optochin Resistance in Streptococcus Pneumoniae. J Antimicrob Chemother. 2008 Nov;62(5):973-7. [3]. Nassira Mahmoudi, et al. Identification of New Antimalarial Drugs by Linear Discriminant Analysis and Topological Virtual Screening. J Antimicrob Chemother. 2006 Mar;57(3):489-97. [4]. Antonella Di Pizio, et al. Molecular Features Underlying Selectivity in Chicken Bitter Taste Receptors. Front Mol Biosci. 2018 Jan 31;5:6.

Target

S. pneumoniae[1] IC50: 25.75 nM (Plasmodium falciparum)[3] ggTas2r1, ggTas2r2 and ggTas2r7[4]

Additional Information

[1]. J A Kolmer, et al. CHEMOTHERAPEUTIC STUDIES WITH ETHYLHYDROCUPREINE HYDROCHLORIDE IN EXPERIMENTAL PNEUMOCOCCUS PLEURITIS. J Exp Med. 1921 May 31;33(6):693-711. [2]. Paulo R Cortes, et al. Subinhibitory Concentrations of Penicillin Increase the Mutation Rate to Optochin Resistance in Streptococcus Pneumoniae. J Antimicrob Chemother. 2008 Nov;62(5):973-7. [3]. Nassira Mahmoudi, et al. Identification of New Antimalarial Drugs by Linear Discriminant Analysis and Topological Virtual Screening. J Antimicrob Chemother. 2006 Mar;57(3):489-97. [4]. Antonella Di Pizio, et al. Molecular Features Underlying Selectivity in Chicken Bitter Taste Receptors. Front Mol Biosci. 2018 Jan 31;5:6.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Ethylhydrocupreine?

The CAS number of Ethylhydrocupreine is 522-60-1.

What are the molecular formula and molecular weight of Ethylhydrocupreine?

Ethylhydrocupreine has molecular formula C21H28N2O2 and molecular weight 340.45900 g/mol.

Is Ethylhydrocupreine hazardous?

Ethylhydrocupreine has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Ethylhydrocupreine (CAS 522-60-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1958221-8 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.