Nordihydroguaiaretic acid
去甲二氢愈创木酸
Also known as: NDGA, Masoprocol, 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol, 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane, 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(1,2-benzenediol), Actinex, Dihydronorguaiaretic acid, Dinorguaiaretic acid, dihydro-, beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane, meso-Nordihydroguaiaretic acid, 1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-
Nordihydroguaiaretic acid (CAS 500-38-9) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C18H22O4 and a molecular weight of 302.365 g/mol. It is also known as NDGA, Masoprocol and 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol. Key properties include a melting point of 184-189ºC, a boiling point of 526.5±45.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 247.8±23.3 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed, H315 — Causes skin irritation and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 500-38-9
- Jingsj CID
- J-1990119-0
- Molecular Formula
- C18H22O4
- Chinese Name
- 去甲二氢愈创木酸
- Molecular Weight
- 302.365 g/mol
- Category
- Organic Acids
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 184-189ºC |
|---|---|
| Boiling Point | 526.5±45.0 °C at 760 mmHg |
| Density | 1.2±0.1 g/cm3 |
| Flash Point | 247.8±23.3 °C |
| Exact Mass | 302.151794 |
| PSA | 80.92000 |
| LogP | 3.71 |
| Vapor Pressure | 0.0±1.4 mmHg at 25°C |
| Refractive Index | 1.627 |
| Additional Property | slightly soluble |
GHS Safety & Compliance
- H302 — Harmful if swallowed
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Target | IC50: 8±3 μM (5LOX)[1] |
|---|---|
| Additional Information | [1]. West M, et al. The arachidonic acid 5-lipoxygenase inhibitor Nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice. J Neurochem. 2004 Oct;91(1):133-43. [2]. Lu F, et al. Virtual Screening for Potential Allosteric Inhibitors of Cyclin-Dependent Kinase 2 from Traditional Chinese Medicine. Molecules. 2016 Sep 21;21(9). pii: E1259. [3]. Zhang H, et al. Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and -independent pathways. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304(1):G72-86. |
Customs & Trade Information
| HS Code | 2907299090 |
|---|---|
| Summary | 2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0% |
Frequently Asked Questions
What is the CAS number of Nordihydroguaiaretic acid?
The CAS number of Nordihydroguaiaretic acid is 500-38-9.
What are the molecular formula and molecular weight of Nordihydroguaiaretic acid?
Nordihydroguaiaretic acid has molecular formula C18H22O4 and molecular weight 302.365 g/mol.
Is Nordihydroguaiaretic acid hazardous?
Nordihydroguaiaretic acid has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H315 — Causes skin irritation; H319 — Causes serious eye irritation.
What are the upstream and downstream products of Nordihydroguaiaretic acid?
For Nordihydroguaiaretic acid, Upstream Products: L-Phenylalanine; Downstream Products: Catechol.
Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Nordihydroguaiaretic acid (CAS 500-38-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1990119-0 (accessed 2026-10-28).
Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.