Betulinic acid

Also known as: Betulinic acid, Mairin, Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3β)-, 3β-Hydroxy-20(29)-lupene-28-oic acid, Betulic acid, ALS-357, Platanol, Gratiolone, Melaleucin

Betulinic acid (CAS 472-15-1) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C30H48O3 and a molecular weight of 456.700 g/mol. Key properties include a melting point of 295-298 °C (dec.)(lit.), a boiling point of 550.0±33.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 300.5±21.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 472-15-1
Jingsj CID: J-35557-5
Molecular Formula: C₃₀H₄₈O₃
Molecular Weight: 456.700 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	295-298 °C (dec.)(lit.)
Boiling Point	550.0±33.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	300.5±21.9 °C
Exact Mass	456.360352
PSA	57.53000
LogP	8.94
Vapor Pressure	0.0±3.4 mmHg at 25°C
Refractive Index	1.533

Activity & Biological Data

Target	Topoisomerase I:5 μM (IC50) HIV-1:1.4 μM (EC50)
Additional Information	[1]. Chowdhury AR, et al. Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives. Med Sci Monit. 2002 Jul;8(7):BR254-65. [2]. Gao Y, et al. Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. 2018 Jan-Feb;42(1):49-54. [3]. Kalra J, et al. Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain in mice. Naunyn Schmiedebergs Arch Pharmacol. 2017 Dec 26. [4]. Hashimoto F, et al. Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives. Bioorg Med Chem. 1997 Dec;5(12):2133-43.

Target

Topoisomerase I:5 μM (IC50) HIV-1:1.4 μM (EC50)

Additional Information

[1]. Chowdhury AR, et al. Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives. Med Sci Monit. 2002 Jul;8(7):BR254-65. [2]. Gao Y, et al. Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. 2018 Jan-Feb;42(1):49-54. [3]. Kalra J, et al. Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain in mice. Naunyn Schmiedebergs Arch Pharmacol. 2017 Dec 26. [4]. Hashimoto F, et al. Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives. Bioorg Med Chem. 1997 Dec;5(12):2133-43.

Customs & Trade Information

HS Code	2918199090
Summary	2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Betulinic acid?

The CAS number of Betulinic acid is 472-15-1.

What are the molecular formula and molecular weight of Betulinic acid?

Betulinic acid has molecular formula C30H48O3 and molecular weight 456.700 g/mol.

What are the upstream and downstream products of Betulinic acid?

For Betulinic acid, Upstream Products: Betulinaldehyde, Betulin, Betulonic acid; Downstream Products: Betulin, Betulinaldehyde, Betulonic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Betulinic acid (CAS 472-15-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-35557-5 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.