(+)-Nootkatone

Also known as: Nootkatone, 4βH,5α-Eremophila-1(10),11-dien-2-one, (4R,4aS,6R)-4,4a-Dimethyl-6-(prop-1-en-2-yl)-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one, Nootkanone

(+)-Nootkatone (CAS 4674-50-4) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C15H22O and a molecular weight of 218.335 g/mol. Key properties include a melting point of 35-39ºC, a boiling point of 318.6±42.0 °C at 760 mmHg, a density of 1.0±0.1 g/cm3 and a flash point of 142.1±18.7 °C. It is classified under GHS with signal word Warning and hazard statements H317 — May cause an allergic skin reaction. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 4674-50-4
Jingsj CID: J-12406-3
Molecular Formula: C₁₅H₂₂O
Molecular Weight: 218.335 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	35-39ºC
Boiling Point	318.6±42.0 °C at 760 mmHg
Density	1.0±0.1 g/cm3
Flash Point	142.1±18.7 °C
Exact Mass	218.167068
PSA	17.07000
LogP	3.84
Vapor Pressure	0.0±0.7 mmHg at 25°C
Refractive Index	1.503
Additional Property	Slightly soluble in ethanol and chloroform. Partly soluble in water.

GHS Safety & Compliance

IrritantSignal word: Warning

H317 — May cause an allergic skin reaction

Activity & Biological Data

Additional Information	[1]. Wang Y, et al. Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease. Int Immunopharmacol. 2018 Sep;62:77-85. [2]. Wang Y, et al. Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease. Int Immunopharmacol. 2018 Sep;62:77-85.

Additional Information

[1]. Wang Y, et al. Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease. Int Immunopharmacol. 2018 Sep;62:77-85. [2]. Wang Y, et al. Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease. Int Immunopharmacol. 2018 Sep;62:77-85.

Frequently Asked Questions

What is the CAS number of (+)-Nootkatone?

The CAS number of (+)-Nootkatone is 4674-50-4.

What are the molecular formula and molecular weight of (+)-Nootkatone?

(+)-Nootkatone has molecular formula C15H22O and molecular weight 218.335 g/mol.

Is (+)-Nootkatone hazardous?

(+)-Nootkatone has GHS signal word Warning and hazard statements H317 — May cause an allergic skin reaction.

What are the upstream and downstream products of (+)-Nootkatone?

For (+)-Nootkatone, Upstream Products: eremophilene, (1R)-(+)-Nopinone; Downstream Products: (4R,4aS)-4,4a,5,6,7,8-Hexahydro-4,4a-dimethyl-6-(1-methylethylidene)naphthalen-2(3H)-one.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "(+)-Nootkatone (CAS 4674-50-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-12406-3 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.