Protriptyline

普罗替林

Also known as: 3-(dibenzo[a,d]cyclohepten-5-yl)propylmethylamine, 5-(3-Methylaminopropyl)-5H-dibenzo[a,d]cycloheptene, 5H-Dibenzo[a,d]cycloheptene-5-propylamine, N-methyl-, Amimetilina, MK 240, N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine, Protriptylin, Protryptyline, Triptil, Vivactil

Protriptyline (CAS 438-60-8) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C19H21N and a molecular weight of 263.37700 g/mol. It is also known as 3-(dibenzo[a,d]cyclohepten-5-yl)propylmethylamine, 5-(3-Methylaminopropyl)-5H-dibenzo[a,d]cycloheptene and 5H-Dibenzo[a,d]cycloheptene-5-propylamine, N-methyl-. Key properties include a boiling point of 407.7ºC at 760 mmHg, a density of 1.026 g/cm3 and a flash point of 198.3ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 438-60-8
Jingsj CID: J-1973114-6
Molecular Formula: C₁₉H₂₁N
Chinese Name: 普罗替林
Molecular Weight: 263.37700 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	407.7ºC at 760 mmHg
Density	1.026 g/cm3
Flash Point	198.3ºC
Exact Mass	263.16700
PSA	12.03000
LogP	4.69280

Activity & Biological Data

Additional Information	[1]. Bansode SB, et, al. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9(8):e105196. [2]. Chang HT, et, al. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35(5):429-34. [3]. Tiwari V, et, al. Protriptyline improves spatial memory and reduces oxidative damage by regulating NFκB-BDNF/CREB signaling axis in streptozotocin-induced rat model of Alzheimer's disease. Brain Res. 2021 Mar 1;1754:147261.

Additional Information

[1]. Bansode SB, et, al. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9(8):e105196. [2]. Chang HT, et, al. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35(5):429-34. [3]. Tiwari V, et, al. Protriptyline improves spatial memory and reduces oxidative damage by regulating NFκB-BDNF/CREB signaling axis in streptozotocin-induced rat model of Alzheimer's disease. Brain Res. 2021 Mar 1;1754:147261.

Customs & Trade Information

HS Code	2921499090
Summary	2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Protriptyline?

The CAS number of Protriptyline is 438-60-8.

What are the molecular formula and molecular weight of Protriptyline?

Protriptyline has molecular formula C19H21N and molecular weight 263.37700 g/mol.

What are the upstream and downstream products of Protriptyline?

For Protriptyline, Upstream Products: 5-[3-(dimethylamino)propyl]-5H-dibenzo[a,d]cyclohepten-5-ol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Protriptyline (CAS 438-60-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1973114-6 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.