4-Hydroxybenzylidenemalononitrile
4-羟基苯亚甲基丙二腈
Also known as: Tyrphostin A8, Tyrphostin AG 10, AG 10, 2-[(4-Hydroxyphenyl)methylene]malononitrile, Propanedinitrile, 2-[(4-hydroxyphenyl)methylene]-, p-Hydroxybenzylidenemalononitrile, Tyrphostin 8, 2-(4-Hydroxybenzylidene)malononitrile
4-Hydroxybenzylidenemalononitrile (CAS 3785-90-8) is a compound in the Aromatic Hydrocarbons category listed in the Jingsj chemical database. It has the molecular formula C10H6N2O and a molecular weight of 170.17 g/mol. It is also known as Tyrphostin A8, Tyrphostin AG 10 and AG 10. Key properties include a melting point of 186-189 °C, a boiling point of 354.3ºC at 760 mmHg, a density of 1.29 g/cm3 and a flash point of 168.1ºC. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 3785-90-8
- Jingsj CID
- J-17047-9
- Molecular Formula
- C10H6N2O
- Chinese Name
- 4-羟基苯亚甲基丙二腈
- Molecular Weight
- 170.17 g/mol
- Category
- Aromatic Hydrocarbons
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 186-189 °C |
|---|---|
| Boiling Point | 354.3ºC at 760 mmHg |
| Density | 1.29 g/cm3 |
| Flash Point | 168.1ºC |
| Exact Mass | 170.04800 |
| PSA | 67.81000 |
| LogP | 1.82276 |
| Refractive Index | 1.653 |
| Additional Property | ethanol: 20 mg/mL, clear |
GHS Safety & Compliance
- H301 — Toxic if swallowed
- H319 — Causes serious eye irritation
Activity & Biological Data
| Target | EGFR:560 μM (IC50) calcineuin phosphatase:21 μM (IC50) |
|---|---|
| Additional Information | [1]. Soltoff SP. Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J Biol Chem. 2004 Mar 19;279(12):10910-8. [2]. Xia CQ, et, al. Tyrphostin-8 enhances transferrin receptor-mediated transcytosis in Caco-2- cells and inreases hypoglycemic effect of orally administered insulin-transferrin conjugate in diabetic rats. Pharm Res. 2001 Feb;18(2):191-5. [3]. Martin BL. Inhibition of calcineurin by the tyrphostin class of tyrosine kinase inhibitors. Biochem Pharmacol. 1998 Aug 15;56(4):483-8. |
Customs & Trade Information
| HS Code | 2926909090 |
|---|---|
| Summary | HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
Frequently Asked Questions
What is the CAS number of 4-Hydroxybenzylidenemalononitrile?
The CAS number of 4-Hydroxybenzylidenemalononitrile is 3785-90-8.
What are the molecular formula and molecular weight of 4-Hydroxybenzylidenemalononitrile?
4-Hydroxybenzylidenemalononitrile has molecular formula C10H6N2O and molecular weight 170.17 g/mol.
Is 4-Hydroxybenzylidenemalononitrile hazardous?
4-Hydroxybenzylidenemalononitrile has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H319 — Causes serious eye irritation.
What are the upstream and downstream products of 4-Hydroxybenzylidenemalononitrile?
For 4-Hydroxybenzylidenemalononitrile, Upstream Products: 4-Hydroxybenzaldehyde, Malononitrile, Potassium phenoxide; Downstream Products: Tyrphostin A63.
Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "4-Hydroxybenzylidenemalononitrile (CAS 3785-90-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-17047-9 (accessed 2026-10-28).
Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.