Procarbazine hydrochloride

盐酸丙卡巴肼

Also known as: Matulane, Ibenzmethyzine hydrochloride, NSC-77213, N-(1-Methylethyl)-4-[(2-methylhydrazino)methyl]benzamide hydrochloride, p-Toluamide, N-isopropyl-α-(2-methylhydrazino)-, monohydrochloride, 4-[(2-methylhydrazinyl)methyl]-N-(propan-2-yl)benzamide hydrochloride (1:1), N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide hydrochloride (1:1), Procarbazine HCl, Procarbazine Hydrochloride USP

Procarbazine hydrochloride (CAS 366-70-1) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C12H20ClN3O and a molecular weight of 257.760 g/mol. It is also known as Matulane, Ibenzmethyzine hydrochloride and NSC-77213. Key properties include a melting point of 223ºC, a boiling point of 384.6ºC at 760 mmHg and a flash point of 148.9ºC. It is classified under GHS with signal word Danger and hazard statements H302 — Harmful if swallowed, H341 — Suspected of causing genetic defects and H350 — May cause cancer. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 366-70-1
Jingsj CID: J-1961627-2
Molecular Formula: C₁₂H₂₀ClN₃O
Chinese Name: 盐酸丙卡巴肼
Molecular Weight: 257.760 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	223ºC
Boiling Point	384.6ºC at 760 mmHg
Flash Point	148.9ºC
Exact Mass	257.129486
PSA	53.16000
LogP	3.02350
Storage Conditions	-20°C Freezer
Additional Property	>=10 g/100 mL at 21.5 ºC

GHS Safety & Compliance

Irritant / Health HazardSignal word: Danger

H302 — Harmful if swallowed
H341 — Suspected of causing genetic defects
H350 — May cause cancer
H360 — May damage fertility or the unborn child

Activity & Biological Data

Additional Information	[1]. Erikson JM, et al. Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L1210 tumor cells. Cancer Res. 1989 Jan 1;49(1):127-33. [2]. Suzuki T, et al. Procarbazine genotoxicity in the MutaMouse; strong clastogenicity and organ-specific induction of lacZ mutations. Mutat Res. 1999 Aug 18;444(2):269-81. [3]. Weissenberg R, et al. Procarbazine effects on spermatogenesis in golden hamster: a flow cytometric evaluation. Arch Androl. 2002 Mar-Apr;48(2):91-100.

Additional Information

[1]. Erikson JM, et al. Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L1210 tumor cells. Cancer Res. 1989 Jan 1;49(1):127-33. [2]. Suzuki T, et al. Procarbazine genotoxicity in the MutaMouse; strong clastogenicity and organ-specific induction of lacZ mutations. Mutat Res. 1999 Aug 18;444(2):269-81. [3]. Weissenberg R, et al. Procarbazine effects on spermatogenesis in golden hamster: a flow cytometric evaluation. Arch Androl. 2002 Mar-Apr;48(2):91-100.

Customs & Trade Information

HS Code	2928000090
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Procarbazine hydrochloride?

The CAS number of Procarbazine hydrochloride is 366-70-1.

What are the molecular formula and molecular weight of Procarbazine hydrochloride?

Procarbazine hydrochloride has molecular formula C12H20ClN3O and molecular weight 257.760 g/mol.

Is Procarbazine hydrochloride hazardous?

Procarbazine hydrochloride has GHS signal word Danger and hazard statements H302 — Harmful if swallowed; H341 — Suspected of causing genetic defects; H350 — May cause cancer.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Procarbazine hydrochloride (CAS 366-70-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1961627-2 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.