Nocodazole
诺考达唑
Also known as: Oncodazole, R 17934, Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate, Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate, Methyl [5-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate, Methyl 5-(2-thienoyl)-2-benzimidazolecarbamate, Nocodazol, N-(6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl)carbamic acid methyl ester, [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbamic acid methyl ester
Nocodazole (CAS 31430-18-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C14H11N3O3S and a molecular weight of 301.320 g/mol. It is also known as Oncodazole, R 17934 and Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate. Key properties include a melting point of 300 °C (dec.) and a density of 1.5±0.1 g/cm3. It is classified under GHS with signal word Warning and hazard statements H341 — Suspected of causing genetic defects. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 31430-18-9
- Jingsj CID
- J-28054-9
- Molecular Formula
- C14H11N3O3S
- Chinese Name
- 诺考达唑
- Molecular Weight
- 301.320 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 300 °C (dec.) |
|---|---|
| Density | 1.5±0.1 g/cm3 |
| Exact Mass | 301.052124 |
| PSA | 112.32000 |
| LogP | 2.43 |
| Refractive Index | 1.732 |
| Additional Property | DMSO: 10 mg/mL, soluble |
GHS Safety & Compliance
- H341 — Suspected of causing genetic defects
Activity & Biological Data
| Target | Abl:91 nM (Kd) ABL(E255K):120 nM (Kd) ABL(T315I):170 nM (Kd) BRAF:1.8 μM (Kd) BRAF(V600E):1.1 μM (Kd) c-KIT:1.6 μM (Kd) MEK1:1.7 μM (Kd) MEK2:1.6 μM (Kd) MET:1.7 μM (Kd) PI3Kγ:1.5 μM (Kd) Microtubule/Tubulin CRISPR/Cas9 |
|---|---|
| Additional Information | [1]. Park H, et al. Nocodazole is a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK. ChemMedChem. 2012 Jan 2;7(1):53-6. [2]. Keliang Xu, et al. Interaction of nocodazole with tubulin isotypes. Drug Development Research 2002 [3]. Long BH, et al. Paclitaxel inhibits progression of mitotic cells to G1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase. Cancer Res. 1994 Aug 15;54(16):4355-61. [4]. Wang YJ, et al. Ketoconazole potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice. Mol Carcinog. 2002 Aug;34(4):199-210. [5]. Signoretto E, et al. Nocodazole Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem. 2016;38(1):379-92. [6]. Zhang JP, et al. Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage. Genome Biol. 2017 Feb 20;18(1):35. |
Customs & Trade Information
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Nocodazole?
The CAS number of Nocodazole is 31430-18-9.
What are the molecular formula and molecular weight of Nocodazole?
Nocodazole has molecular formula C14H11N3O3S and molecular weight 301.320 g/mol.
Is Nocodazole hazardous?
Nocodazole has GHS signal word Warning and hazard statements H341 — Suspected of causing genetic defects.
Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Nocodazole (CAS 31430-18-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-28054-9 (accessed 2026-10-28).
Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.