4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one

4-(3-丁氧基-4-甲氧基苯基)咪唑啶-2-酮

Also known as: RO 20-1724, RO20-1724, R020-1724, ROCHE 20-1724, 2-Imidazolidinone,4-(3-butoxy-4-methoxybenzyl)- (8CI), 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone, 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidone, DL-4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone

4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one (CAS 29925-17-5) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C15H22N2O3 and a molecular weight of 278.35 g/mol. It is also known as RO 20-1724, RO20-1724 and R020-1724. Key properties include a boiling point of 483.8ºC at 760 mmHg, a density of 1.099 g/cm3 and a flash point of 246.4ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 29925-17-5
Jingsj CID: J-4668-4
Molecular Formula: C₁₅H₂₂N₂O₃
Chinese Name: 4-(3-丁氧基-4-甲氧基苯基)咪唑啶-2-酮
Molecular Weight: 278.35 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

No offers for this compound yet.

Request a quote

Physicochemical Properties

Boiling Point	483.8ºC at 760 mmHg
Density	1.099 g/cm3
Flash Point	246.4ºC
Exact Mass	278.16300
PSA	59.59000
LogP	2.75560
Vapor Pressure	1.62E-09mmHg at 25°C
Refractive Index	1.521
Additional Property	ethanol: 7 mg/mL

Activity & Biological Data

Target	PDE4:1930 nM (Ki)
Additional Information	[1]. Brackeen MF, et al. Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase. J Med Chem. 1995;38(24):4848-4854. [2]. Sharma V, et al. Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav. 2012;101(2):239-245.

Target

PDE4:1930 nM (Ki)

Additional Information

[1]. Brackeen MF, et al. Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase. J Med Chem. 1995;38(24):4848-4854. [2]. Sharma V, et al. Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav. 2012;101(2):239-245.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one?

The CAS number of 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one is 29925-17-5.

What are the molecular formula and molecular weight of 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one?

4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one has molecular formula C15H22N2O3 and molecular weight 278.35 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one (CAS 29925-17-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-4668-4 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.