Nalbuphine hydrochloride

盐酸纳布啡

Also known as: Nalbuphine hydrochloride hydrate, Nalbuphine HCl, Nubain, (4R,4aS,7S,7aR,12bS)-3-(cyclobutylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol hydrochloride, 17-(Cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol hydrochloride hydrate

Nalbuphine hydrochloride (CAS 23277-43-2) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C21H28ClNO4 and a molecular weight of 393.90400 g/mol. It is also known as Nalbuphine hydrochloride hydrate, Nalbuphine HCl and Nubain. Key properties include a melting point of 230.5ºC, a boiling point of 566.6ºC at 760 mmHg and a flash point of 296.5ºC. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour, H301 — Toxic if swallowed and H311 — Toxic in contact with skin. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 23277-43-2
Jingsj CID: J-1524011-4
Molecular Formula: C₂₁H₂₈ClNO₄
Chinese Name: 盐酸纳布啡
Molecular Weight: 393.90400 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	230.5ºC
Boiling Point	566.6ºC at 760 mmHg
Flash Point	296.5ºC
Exact Mass	393.17100
PSA	73.16000
LogP	2.44720
Vapor Pressure	1.12E-13mmHg at 25°C
Storage Conditions	?20°C
Additional Property	H2O: soluble

GHS Safety & Compliance

Flammable / Acute Toxicity / Health HazardSignal word: Danger

H225 — Highly flammable liquid and vapour
H301 — Toxic if swallowed
H311 — Toxic in contact with skin
H330 — Fatal if inhaled
H370 — Causes damage to organs

Frequently Asked Questions

What is the CAS number of Nalbuphine hydrochloride?

The CAS number of Nalbuphine hydrochloride is 23277-43-2.

What are the molecular formula and molecular weight of Nalbuphine hydrochloride?

Nalbuphine hydrochloride has molecular formula C21H28ClNO4 and molecular weight 393.90400 g/mol.

Is Nalbuphine hydrochloride hazardous?

Nalbuphine hydrochloride has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H301 — Toxic if swallowed; H311 — Toxic in contact with skin.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Nalbuphine hydrochloride (CAS 23277-43-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1524011-4 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.