alpha-Amanitin

α-毒伞肽

Also known as: alpha-Amanitine, α-Amatoxin, Amanitin, cyclo[L-Asparaginyl-4-hydroxy-L-prolyl-(R)-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl] cyclic (4→8)-sulfide (R)-S-oxide

alpha-Amanitin (CAS 23109-05-9) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C39H54N10O14S and a molecular weight of 918.97000 g/mol. It is also known as alpha-Amanitine, α-Amatoxin and Amanitin. Key properties include a melting point of 254-255ºC(lit.), a boiling point of 1622.2ºC at 760 mmHg, a density of 1.57 g/cm3 and a flash point of 934.9ºC. It is classified under GHS with signal word Danger and hazard statements H300, H310 and H330 — Fatal if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 23109-05-9
Jingsj CID: J-1991450-9
Molecular Formula: C₃₉H₅₄N₁₀O₁₄S
Chinese Name: α-毒伞肽
Molecular Weight: 918.97000 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	254-255ºC(lit.)
Boiling Point	1622.2ºC at 760 mmHg
Density	1.57 g/cm3
Flash Point	934.9ºC
Exact Mass	918.35400
PSA	400.09000
Refractive Index	1.694
Storage Conditions	-20℃

GHS Safety & Compliance

Acute Toxicity / Health HazardSignal word: Danger

H300
H310
H330 — Fatal if inhaled
H373 — May cause damage to organs through prolonged exposure

Activity & Biological Data

Target	ADCs cytotoxin, RNA-polymerase II[1]
Additional Information	[1]. Zhao J, et al. Pathological effects of the mushroom toxin alpha-amanitin on BALB/c mice. Peptides. 2006 Dec;27(12):3047-3052. [2]. Kume K, et al. α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF15. Sci Rep. 2016 May 16;6:25895 [3]. Kaya E, et al. Evaluation and comparison of alpha- and beta-amanitin toxicity on MCF-7 cell line. Turk J Med Sci. 2014;44(5):728-32 [4]. Park MW, et al. RNA Polymerase II Inhibitor, α-Amanitin, Affects Gene Expression for Gap Junctions and Metabolic Capabilities of Cumulus Cells, but Not Oocyte, during in vitro Mouse Oocyte Maturation. Dev Reprod. 2013 Mar;17(1):63-72

Target

ADCs cytotoxin, RNA-polymerase II[1]

Additional Information

[1]. Zhao J, et al. Pathological effects of the mushroom toxin alpha-amanitin on BALB/c mice. Peptides. 2006 Dec;27(12):3047-3052. [2]. Kume K, et al. α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF15. Sci Rep. 2016 May 16;6:25895 [3]. Kaya E, et al. Evaluation and comparison of alpha- and beta-amanitin toxicity on MCF-7 cell line. Turk J Med Sci. 2014;44(5):728-32 [4]. Park MW, et al. RNA Polymerase II Inhibitor, α-Amanitin, Affects Gene Expression for Gap Junctions and Metabolic Capabilities of Cumulus Cells, but Not Oocyte, during in vitro Mouse Oocyte Maturation. Dev Reprod. 2013 Mar;17(1):63-72

Frequently Asked Questions

What is the CAS number of alpha-Amanitin?

The CAS number of alpha-Amanitin is 23109-05-9.

What are the molecular formula and molecular weight of alpha-Amanitin?

alpha-Amanitin has molecular formula C39H54N10O14S and molecular weight 918.97000 g/mol.

Is alpha-Amanitin hazardous?

alpha-Amanitin has GHS signal word Danger and hazard statements H300; H310; H330 — Fatal if inhaled.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "alpha-Amanitin (CAS 23109-05-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1991450-9 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.