Hydroxocobalamin Acetate

羟钴胺醋酸盐

Also known as: Acetatocobalamin, Vitamin B12a acetate, Hydroxycobalamin acetate, Hydroxycobalamine acetate, Depo-gamma, Fresmin S, Novidroxin, Twelvmin, Acetato-cobalamin

Hydroxocobalamin Acetate (CAS 22465-48-1) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C64H91CoN13O16P and a molecular weight of 1388.39000 g/mol. It is also known as Acetatocobalamin, Vitamin B12a acetate and Hydroxycobalamin acetate. Key property: a melting point of >300ºC.. It is classified under GHS with signal word Warning and hazard statements H351 — Suspected of causing cancer. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 22465-48-1
Jingsj CID: J-1981296-6
Molecular Formula: C₆₄H₉₁CoN₁₃O₁₆P
Chinese Name: 羟钴胺醋酸盐
Molecular Weight: 1388.39000 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	>300ºC.
Exact Mass	1387.58000
PSA	490.17000
LogP	6.62930

GHS Safety & Compliance

Health HazardSignal word: Warning

H351 — Suspected of causing cancer

Activity & Biological Data

Target	The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide (NO) and hydroxocobalamin attenuates vascular responses to NO in vitro[3].
Additional Information	[1]. Cheungpasitporn W, et al. High-dose hydroxocobalamin for vasoplegic syndrome causing false blood leak alarm. Clin Kidney J. 2017 Jun;10(3):357-362. [2]. Wang H, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018 Mar 15;3:CD004655. [3]. Greenberg SS, et al. Hydroxocobalamin (vitamin B12a) prevents and reverses endotoxin-induced hypotension and mortality in rodents: role of nitric oxide. J Pharmacol Exp Ther. 1995 Apr;273(1):257-65.

Target

The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide (NO) and hydroxocobalamin attenuates vascular responses to NO in vitro[3].

Additional Information

[1]. Cheungpasitporn W, et al. High-dose hydroxocobalamin for vasoplegic syndrome causing false blood leak alarm. Clin Kidney J. 2017 Jun;10(3):357-362. [2]. Wang H, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018 Mar 15;3:CD004655. [3]. Greenberg SS, et al. Hydroxocobalamin (vitamin B12a) prevents and reverses endotoxin-induced hypotension and mortality in rodents: role of nitric oxide. J Pharmacol Exp Ther. 1995 Apr;273(1):257-65.

Frequently Asked Questions

What is the CAS number of Hydroxocobalamin Acetate?

The CAS number of Hydroxocobalamin Acetate is 22465-48-1.

What are the molecular formula and molecular weight of Hydroxocobalamin Acetate?

Hydroxocobalamin Acetate has molecular formula C64H91CoN13O16P and molecular weight 1388.39000 g/mol.

Is Hydroxocobalamin Acetate hazardous?

Hydroxocobalamin Acetate has GHS signal word Warning and hazard statements H351 — Suspected of causing cancer.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Hydroxocobalamin Acetate (CAS 22465-48-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1981296-6 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.