Benfotiamine

苯磷硫胺

Also known as: S-benzoylthiamine O-monophosphate, S-benzoylthiamine monophosphate, S-benzoylthiamine-O-monophosphate, Benzoylthiamine O-monophosphate, Benphothiamine, Biotamin, Betivina, Berdi, Milgamma, Neurostop, Nitanevril, Tabiomyl

Benfotiamine (CAS 22457-89-2) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C19H23N4O6PS and a molecular weight of 466.448 g/mol. It is also known as S-benzoylthiamine O-monophosphate, S-benzoylthiamine monophosphate and S-benzoylthiamine-O-monophosphate. Key properties include a melting point of 165ºC, a boiling point of 745.1±70.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 404.4±35.7 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 22457-89-2
Jingsj CID: J-1972610-6
Molecular Formula: C₁₉H₂₃N₄O₆PS
Chinese Name: 苯磷硫胺
Molecular Weight: 466.448 g/mol
Category: Organic Bases
Last updated: 8/21/2026

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	165ºC
Boiling Point	745.1±70.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	404.4±35.7 °C
Exact Mass	466.107605
PSA	191.05000
LogP	1.81
Vapor Pressure	0.0±2.6 mmHg at 25°C
Refractive Index	1.645
Storage Conditions	2-8°C

Activity & Biological Data

Additional Information	[1]. Tarallo S, Beltramo E, Berrone E, Porta M. Human pericyte-endothelial cell interactions in co-culture models mimicking the diabetic retinal microvascular environment. Acta Diabetol. 2012 Dec;49 Suppl 1:141-51. [2]. Engelen L, Stehouwer CD, Schalkwijk CG. Current therapeutic interventions in the glycation pathway:Evidence from clinical studies. Diabetes Obes Metab. 2012 Dec 26. [3]. Hurt JK, Coleman JL, Fitzpatrick BJ, et al. Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. PLoS One. 2012;7(10):e48562. [4]. Hans-Peter Hammes, Xueliang Du, Diane Edelstein, et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nature Medicine, 2003, 9, 294 - 299 [5]. Loew D. Pharmacokinetics of thiamine derivatives especially of benfotiamine. International Journal of Clinical Pharmacology and Therapeutics, 1996, 34(2):47-50 [6]. Benfotiamine

Additional Information

[1]. Tarallo S, Beltramo E, Berrone E, Porta M. Human pericyte-endothelial cell interactions in co-culture models mimicking the diabetic retinal microvascular environment. Acta Diabetol. 2012 Dec;49 Suppl 1:141-51. [2]. Engelen L, Stehouwer CD, Schalkwijk CG. Current therapeutic interventions in the glycation pathway:Evidence from clinical studies. Diabetes Obes Metab. 2012 Dec 26. [3]. Hurt JK, Coleman JL, Fitzpatrick BJ, et al. Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. PLoS One. 2012;7(10):e48562. [4]. Hans-Peter Hammes, Xueliang Du, Diane Edelstein, et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nature Medicine, 2003, 9, 294 - 299 [5]. Loew D. Pharmacokinetics of thiamine derivatives especially of benfotiamine. International Journal of Clinical Pharmacology and Therapeutics, 1996, 34(2):47-50 [6]. Benfotiamine

Frequently Asked Questions

What is the CAS number of Benfotiamine?

The CAS number of Benfotiamine is 22457-89-2.

What are the molecular formula and molecular weight of Benfotiamine?

Benfotiamine has molecular formula C19H23N4O6PS and molecular weight 466.448 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Benfotiamine (CAS 22457-89-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1972610-6 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.