Cucurbitacin I

葫芦素I

Also known as: Elatericin B, JSI-124, NSC 521777, Elaterin B, (9β,10α,16α)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23(E)-triene-3,11,22-trione

Cucurbitacin I (CAS 2222-07-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C30H42O7 and a molecular weight of 514.650 g/mol. It is also known as Elatericin B, JSI-124 and NSC 521777. Key properties include a melting point of 148-150ºC, a boiling point of 716.9±60.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 401.3±29.4 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 2222-07-3
Jingsj CID: J-2182-3
Molecular Formula: C₃₀H₄₂O₇
Chinese Name: 葫芦素I
Molecular Weight: 514.650 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	148-150ºC
Boiling Point	716.9±60.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	401.3±29.4 °C
Exact Mass	514.293030
PSA	132.13000
LogP	2.06
Vapor Pressure	0.0±5.2 mmHg at 25°C
Refractive Index	1.594
Storage Conditions	−20°C

Activity & Biological Data

Target	JAK2 STAT3
Additional Information	[1]. Song J, et al. Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer. Oncol Rep. 2015 Apr;33(4):1867-71. [2]. Jeong MH, et al. Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings. PLoS One. 2015 Aug 21;10(8):e0136236. [3]. van Kester MS, et al. Cucurbitacin I inhibits Stat3 and induces apoptosis in Sézary cells. J Invest Dermatol. 2008 Jul;128(7):1691-5. [4]. Yuan G, et al. Cucurbitacin I induces protective autophagy in glioblastoma in vitro and in vivo. J Biol Chem. 2014 Apr 11;289(15):10607-19.

Target

JAK2 STAT3

Additional Information

[1]. Song J, et al. Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer. Oncol Rep. 2015 Apr;33(4):1867-71. [2]. Jeong MH, et al. Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings. PLoS One. 2015 Aug 21;10(8):e0136236. [3]. van Kester MS, et al. Cucurbitacin I inhibits Stat3 and induces apoptosis in Sézary cells. J Invest Dermatol. 2008 Jul;128(7):1691-5. [4]. Yuan G, et al. Cucurbitacin I induces protective autophagy in glioblastoma in vitro and in vivo. J Biol Chem. 2014 Apr 11;289(15):10607-19.

Frequently Asked Questions

What is the CAS number of Cucurbitacin I?

The CAS number of Cucurbitacin I is 2222-07-3.

What are the molecular formula and molecular weight of Cucurbitacin I?

Cucurbitacin I has molecular formula C30H42O7 and molecular weight 514.650 g/mol.

What are the upstream and downstream products of Cucurbitacin I?

For Cucurbitacin I, Upstream Products: Cucurbitacin E.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Cucurbitacin I (CAS 2222-07-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-2182-3 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.