Neohesperidin dihydrochalcone

新橙皮苷二氢查尔酮

Also known as: Neohesperidin DHC, Neohesperidine dihydrochalcone, Neohesperidin dihydrochalcone hydrate, NHDC, E-959, Dihydrohesperetin-7-O-neohesperidoside, Neohesperidine DC, 1-(4-((2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-1-propanone

Neohesperidin dihydrochalcone (CAS 20702-77-6) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C28H36O15 and a molecular weight of 612.576 g/mol. It is also known as Neohesperidin DHC, Neohesperidine dihydrochalcone and Neohesperidin dihydrochalcone hydrate. Key properties include a melting point of 156-158 °C(lit.), a boiling point of 927.1±65.0 °C at 760 mmHg, a density of 1.6±0.1 g/cm3 and a flash point of 302.6±27.8 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 20702-77-6
Jingsj CID: J-48252-1
Molecular Formula: C₂₈H₃₆O₁₅
Chinese Name: 新橙皮苷二氢查尔酮
Molecular Weight: 612.576 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	156-158 °C(lit.)
Boiling Point	927.1±65.0 °C at 760 mmHg
Density	1.6±0.1 g/cm3
Flash Point	302.6±27.8 °C
Exact Mass	612.205444
PSA	245.29000
LogP	3.09
Vapor Pressure	0.0±0.3 mmHg at 25°C
Refractive Index	1.684
Storage Conditions	-20℃
Additional Property	Insoluble

Activity & Biological Data

Additional Information	[1]. Choi JM, et al. Antioxidant properties of neohesperidin dihydrochalcone: inhibition of hypochlorous acid-induced DNA strand breakage, protein degradation, and cell death. Biol Pharm Bull. 2007 Feb;30(2):324-30. [2]. Kashani-Amin E, et al. Neohesperidin dihydrochalcone: presentation of a small molecule activator of mammalian alpha-amylase as an allosteric effector. FEBS Lett. 2013 Mar 18;587(6):652-8. [3]. Shi Q, et al. Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice. Int Immunopharmacol. 2015 Dec;29(2):722-9. [4]. Waalkens-Berendsen DH, et al. Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats. Regul Toxicol Pharmacol. 2004 Aug;40(1):74-9.

Additional Information

[1]. Choi JM, et al. Antioxidant properties of neohesperidin dihydrochalcone: inhibition of hypochlorous acid-induced DNA strand breakage, protein degradation, and cell death. Biol Pharm Bull. 2007 Feb;30(2):324-30. [2]. Kashani-Amin E, et al. Neohesperidin dihydrochalcone: presentation of a small molecule activator of mammalian alpha-amylase as an allosteric effector. FEBS Lett. 2013 Mar 18;587(6):652-8. [3]. Shi Q, et al. Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice. Int Immunopharmacol. 2015 Dec;29(2):722-9. [4]. Waalkens-Berendsen DH, et al. Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats. Regul Toxicol Pharmacol. 2004 Aug;40(1):74-9.

Customs & Trade Information

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Neohesperidin dihydrochalcone?

The CAS number of Neohesperidin dihydrochalcone is 20702-77-6.

What are the molecular formula and molecular weight of Neohesperidin dihydrochalcone?

Neohesperidin dihydrochalcone has molecular formula C28H36O15 and molecular weight 612.576 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Neohesperidin dihydrochalcone (CAS 20702-77-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-48252-1 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.