Parthenolide

Also known as: (-)-Parthenolide, Germacra-1(10),11(13)-dien-12-oic acid, 4,5α-epoxy-6β-hydroxy-, γ-lactone, Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (4Z)-, MFCD00134592, Nsc157035, PTL

Parthenolide (CAS 20554-84-1) is a compound in the Esters category listed in the Jingsj chemical database. It has the molecular formula C15H20O3 and a molecular weight of 248.318 g/mol. Key properties include a melting point of 115-116ºC(lit.), a boiling point of 394.1±42.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 166.3±22.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 20554-84-1
Jingsj CID: J-2444-4
Molecular Formula: C₁₅H₂₀O₃
Molecular Weight: 248.318 g/mol
Category: Esters
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	115-116ºC(lit.)
Boiling Point	394.1±42.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	166.3±22.5 °C
Exact Mass	248.141251
PSA	38.83000
LogP	2.42
Vapor Pressure	0.0±0.9 mmHg at 25°C
Refractive Index	1.533
Storage Conditions	2-8℃

Activity & Biological Data

Target	NF-κB Autophagy Mitophagy
Additional Information	[1]. Nakshatri H, et al. NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. Cell Death Dis. 2015 Jan 22;6:e1608. [2]. Zhao X, et al. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014 Jan 6;33:3. [3]. Barbier-Torres L, et al. Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1. Hepatology. 2015 Oct;62(4):1237-48.

Target

NF-κB Autophagy Mitophagy

Additional Information

[1]. Nakshatri H, et al. NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. Cell Death Dis. 2015 Jan 22;6:e1608. [2]. Zhao X, et al. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014 Jan 6;33:3. [3]. Barbier-Torres L, et al. Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1. Hepatology. 2015 Oct;62(4):1237-48.

Frequently Asked Questions

What is the CAS number of Parthenolide?

The CAS number of Parthenolide is 20554-84-1.

What are the molecular formula and molecular weight of Parthenolide?

Parthenolide has molecular formula C15H20O3 and molecular weight 248.318 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Parthenolide (CAS 20554-84-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-2444-4 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.