Wortmannin
渥曼青霉素
Also known as: SL-2052, KY 12420, Antibiotic SL-2052, (+)-Wortmannin, Wartmannin, 3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9aS,11R,11bR)-, [1S-(1α,6bα,9aβ,11α,11bβ)]-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione
Wortmannin (CAS 19545-26-7) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C23H24O8 and a molecular weight of 428.432 g/mol. It is also known as SL-2052, KY 12420 and Antibiotic SL-2052. Key properties include a melting point of 234-240ºC, a boiling point of 615.6±55.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 326.1±31.5 °C. It is classified under GHS with signal word Danger and hazard statements H300, H310 and H330 — Fatal if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 19545-26-7
- Jingsj CID
- J-30975-4
- Molecular Formula
- C23H24O8
- Chinese Name
- 渥曼青霉素
- Molecular Weight
- 428.432 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 234-240ºC |
|---|---|
| Boiling Point | 615.6±55.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 326.1±31.5 °C |
| Exact Mass | 428.147125 |
| PSA | 109.11000 |
| LogP | 0.81 |
| Vapor Pressure | 0.0±1.8 mmHg at 25°C |
| Refractive Index | 1.591 |
| Storage Conditions | 2-8°C |
| Additional Property | DMSO: soluble |
GHS Safety & Compliance
- H300
- H310
- H330 — Fatal if inhaled
Activity & Biological Data
| Target | PI3K:3 nM (IC50) ATM:150 nM (IC50) ATR:1.8 μM (IC50) DNA-PK:16 nM (IC50) MLCK:200 nM (IC50) Plk3:48 nM (IC50) |
|---|---|
| Additional Information | [1]. Yano H, et al. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem, 1993, 268(34), 25846-25856. [2]. Sarkaria JN, et al. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res, 1998, 58(19), 4375-4382. [3]. Nakanishi S, et al. Wortmannin, a microbial product inhibitor of myosin light chain kinase. J Biol Chem, 1992, 267(4), 2157-2163. [4]. Ng SS, et al. Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice. Clin Cancer Res, 2001, 7(10), 3269-3275. [5]. Teranishi F, et al. Phosphoinositide 3-kinase inhibitor (wortmannin) inhibits pancreatic cancer cell motility and migration induced by hyaluronan in vitro and peritoneal metastasis in vivo. Cancer Sci. 2009 Apr;100(4):770-7. [6]. Liu Y, et al. Polo-like kinases inhibited by Wortmannin. Labeling site and downstream effects. J Biol Chem. 2007 Jan 26;282(4):2505-11. |
Frequently Asked Questions
What is the CAS number of Wortmannin?
The CAS number of Wortmannin is 19545-26-7.
What are the molecular formula and molecular weight of Wortmannin?
Wortmannin has molecular formula C23H24O8 and molecular weight 428.432 g/mol.
Is Wortmannin hazardous?
Wortmannin has GHS signal word Danger and hazard statements H300; H310; H330 — Fatal if inhaled.
What are the upstream and downstream products of Wortmannin?
For Wortmannin, Upstream Products: 11β-Hydroxyandrost-4-ene-3,17-dione.
Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Wortmannin (CAS 19545-26-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-30975-4 (accessed 2026-10-28).
Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.